Results 11 to 20 of about 46,229 (217)

Investigation into the α-Gal Syndrome: Characteristics of 261 Children and Adults Reporting Red Meat Allergy [PDF]

The Journal of Allergy and Clinical Immunology: In Practice, 2019
Red meat allergy has historically been understood as a rare disease of atopic children, but the discovery of the "α-Gal syndrome," which relates to IgE to the oligosaccharide galactose-α-1,3-galactose (α-Gal), has challenged that notion.To describe the clinical and immunologic characteristics of a large group of subjects with self-reported allergy to ...
Jeffrey M. Wilson, Alexander J. Schuyler, Lisa J. Workman, Monica Gupta, Hayley R. James, Jonathon Posthumus, Emily C. McGowan, Scott P. Commins, Thomas A.E. Platts‐Mills   +8 more
semanticscholar   +6 more sources

The quantity and quality of α-gal-specific antibodies differ in individuals with and without delayed red meat allergy [PDF]

Allergy, 2016
IgG to galactose-α-1,3-galactose (α-gal) are highly abundant natural antibodies (Ab) in humans. α-Gal-specific IgE Ab cause a special form of meat allergy characterized by severe systemic reactions 3-7 h after consumption of red meat. We investigated 20 patients who experienced such reactions and characterized their α-gal-specific IgE and IgG responses
Dagmar Kollmann, Birgit Nagl, C. Ebner, W. Emminger, Stefan Wöhrl, Claudia Kitzmüller, Susanne Vrtala, Andreas Mangold, Hendrik Jan Ankersmit, Barbara Bohle   +9 more
semanticscholar   +6 more sources

The B antigen protects against the development of red meat allergy [PDF]

The Journal of Allergy and Clinical Immunology: In Practice, 2018
Jonathan R. Brestoff, Merih T. Tesfazghi, Mark A. Zaydman, Ronald Jackups, Brian Kim, Mitchell G. Scott, Ann M. Gronowski, Brenda J. Grossman   +7 more
semanticscholar   +7 more sources

Allergenomics of the tick Ixodes ricinus reveals important α‐Gal–carrying IgE‐binding proteins in red meat allergy [PDF]

Allergy, 2019
To the Editor Red meat allergy known as mammalian meat allergy, caused by IgE antibodies against galactose‐α‐1,3‐galactose (α‐Gal), is nowadays recognized worldwide, and strong associations with tick bites have been identified for different tick species ...
Danijela Apostolović, Jelena Mihailović, Scott P. Commins, Michiel Wijnveld, Mária Kazimírová, Maria Starkhammar, Hannes Stockinger, Thomas A.E. Platts‐Mills, Tanja Ćirković Veličković, Carl Hamsten, Marianne van Hage   +10 more
semanticscholar   +3 more sources

Tick bites and red meat allergy [PDF]

Current Opinion in Allergy & Clinical Immunology, 2013
A novel form of anaphylaxis has been described that is due to IgE antibody (Ab) directed against a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal). Ongoing work regarding the cause and distribution of this IgE response is reviewed.Our recent work has identified a novel IgE Ab response that has been associated with two ...
Scott P. Commins, Thomas A.E. Platts‐Mills   +1 more
europepmc   +5 more sources

An integrated framework using high‐dimensional mass cytometry and fluorescent flow cytometry identifies discrete B cell subsets in patients with red meat allergy [PDF]

Clin Exp Allergy, 2018
B cells play a critical role in the development and maintenance of food allergy by producing allergen‐specific IgE. Despite the importance of B cells in IgE‐mediated food allergy, the identity of sIgE‐producing human B cells and how IgE is regulated are ...
Kelly Cox, Scott P. Commins, Brian J. Capaldo, Lisa J. Workman, Thomas A.E. Platts‐Mills, El-ad David Amir, Joanne Lannigan, Alexander J. Schuyler, Loren D. Erickson   +8 more
semanticscholar   +3 more sources

Red meat allergy in Sweden: Association with tick sensitization and B-negative blood groups [PDF]

Journal of Allergy and Clinical Immunology, 2013
Over the past few years, allergy to mammalian meat has been identified as a new syndrome of food allergy presenting as symptoms of delayed severe allergic reactions after consumption of red meat (beef, lamb, or pork).1-4 These allergic reactions are directed against the carbohydrate galactose-α-1,3-galactose (α-Gal).
Carl Hamsten, Thi Anh Thu Tran, Maria Starkhammar, Annelie Brauner, Scott P. Commins, Thomas A.E. Platts‐Mills, Marianne van Hage   +6 more
europepmc   +6 more sources

Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose [PDF]

Journal of Allergy and Clinical Immunology, 2012
We have observed patients clinically allergic to red meat and meat-derived gelatin.We describe a prospective evaluation of the clinical significance of gelatin sensitization, the predictive value of a positive test result, and an examination of the relationship between allergic reactions to red meat and sensitization to gelatin and galactose-α-1,3 ...
Raymond J Mullins, Hayley R. James, Thomas A.E. Platts‐Mills, Scott P. Commins   +3 more
europepmc   +5 more sources

Alpha-Gal Syndrome: An Emerging Tick-Borne Allergy to Red Meat [PDF]

Cureus
Alpha-gal syndrome (AGS) is a delayed-onset food allergy triggered by an immune response to galactose-α-1,3-galactose (alpha-gal), a carbohydrate associated with Lone Star tick bites. A 45-year-old female presented with a 9-month history of nausea and abdominal pain consistently associated with red meat consumption.
Tyanna McCladdie, Michael Herman
europepmc   +4 more sources

Red meat allergy: clinical characteristics

Allergy, Asthma & Respiratory Disease, 2020
Purpose: Red meat allergy has recently been described as rare food hypersensitivity with unique pathogenesis and clinical relevance of delayed anaphylaxis. The culprits are various mammal meats containing oligosaccharide epitope (galactose-α-1,3-galactose, α-gal). Interestingly, hard tick bites precede the onset of this allergic condition. The clinical
Se-Jin Kim, Jaechun Lee, Ara Ko
semanticscholar   +4 more sources