Results 31 to 40 of about 743,057 (300)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Ultrafast Lasing Dynamics in a CsPbBr3 Perovskite Microplate

Advanced Photonics Research, 2022
The perovskite microlaser is a competitive candidate of light source for optical communication and integrated photonic circuits. Understanding the fundamental mechanism of lasing is crucial for the upcoming devices.
Ju Wang, Haoran Yu, Guodong Liu, Wei Liu, Yiqun Duan, Xue Cheng, Lun Dai, Shufeng Wang, Qihuang Gong   +8 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Applications of Computational Protein Design to Red Fluorescent Proteins

, 2013
The research comprising this thesis is presented in three chapters divided into two parts. Part One, Chapters 2 and 3, of the thesis focuses on the application of rational design and CPD to the core residues of FPs.
Moore, Matthew Michaels
core   +1 more source

Ultrasensitive bionic photonic-electronic skin with wide red-shift mechanochromic response

Light: Advanced Manufacturing
Mimicking animal skin is an effective strategy for enhancing the performance of artificial skin. Inspired by a chameleon’s iridophore and a spider’s slit organ, a novel photonic-electronic skin (PE-skin) with excellent optical/electrical dual-sensing ...
Tianqi Wang, Lei Chen, Haogeng Liu, Haoran Zhu, Zijie Zeng, Yixin Lu, Ping Zhang, Yaofei Chen, Yue Huang, Gui-Shi Liu, Yunhan Luo, Zhe Chen   +11 more
doaj   +1 more source

The Electron Spin Resonance (Esr) Spectra of Potassium-Alumina-Borate Glass Doped with Copper Ions

Reviews on Advanced Materials Science, 2018
We investigate electron spin resonance (ESR), absorption, and photoluminescence spectra of potassium-boron copper-containing glasses. In previous works it was found, that the considered glasses demonstrate a red shift of photoluminescence.
Shirshnev P.S., Eremina R.M., Yatsyk I.V., Snezhnaia Zh.G., Panov D.I., Shirshneva-Vaschenko E.V., Romanov A.E., Bougrov V.E.   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Density Functional Theory Study of Raman Modes of Hydrogenated Cadmium Sulphide Nanoparticles

Nanomaterials and Nanotechnology, 2012
Raman scattering investigations based on density functional theory (DFT) calculations were performed to explore the vibrational modes of wurtzite structured CdS nanoparticles (NPs).
Abdul Majid, Raees Ahmad, Azeem Nabi, Abdul Shakoor, Najmul Hassan   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source