Results 91 to 100 of about 407,327 (266)

Nuevas tendencias en el proceso de formación y mentoría de profesores universitarios noveles en su primer año de docencia

Olhar de Professor, 2013
En el presente artículo se describe el programa de iniciación a la docencia de la Universidad de Sevilla a partir de la propia vivencia y se proponen líneas de mejora a cada una de sus fases, entre otras: crear y dinamizar una red social donde profesores
Carmen Yot Domínguez, Cristina Mayor Ruiz   +1 more
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Investigación social en Twitch: un análisis experimental de seis streamers hispanohablantes

Revista Teknokultura
En este artículo se presenta una investigación diacrónica centrada en analizar las formas de interacción vernáculas de las comunidades digitales en Twitch, a través de los chats de los canales de seis streamers hispanohablantes con mayor número de ...
Bárbara Prummer Arabaolaza, Iru Díaz-García, Aileen Chales-Aoun, María Muñoz-Carballo, Gonzalo Carniglia-González   +4 more
doaj   +1 more source

Red social de viajes

, 2020
This project is a final degree project that consists of the development of a mobile application based on a travel social network service. This idea was born from the search for modernization of the current and well-known travel blogs, since it is considered that this concept is out of date comparing it with the technology that exists in the market ...
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Interacción social en la Red

, 2008
Las posibilidades de interacción social que brinda Internet encuentran en los blogs uno de sus máximos exponentes, en tanto que, junto con las otras formas más consolidadas y populares como los chats o los foros, se están convirtiendo en verdaderos "puntos de encuentro" entre personas con intereses e inquietudes comunes.
Perona Páez, Juan José, Barbeito Veloso, Ma. Luz   +1 more
openaire   +4 more sources

Red Social UPV

, 2012
El objetivo de este proyecto es crear una aplicación web que sirva de red social para los alumnos y profesores de la UPV. En este proyecto se trataran todos los puntos decisivos a la hora de crear una página web. Y se abordarán desde la perspectiva de php , html, css, javascript y mysql mezclando todas estas tecnologías para sacar lo mejor de cada una ...
openaire   +2 more sources