Results 71 to 80 of about 407,327 (266)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Redes y organizaciones sociales en el proceso de ocupación del Gran Chaco
Revista de Indias, 2007 El proceso de privatización y concentración territorial es objeto de estudio de este trabajo que analiza la ocupación del Gran Chaco durante las décadas previas a la guerra sostenida por los gobiernos paraguayo y boliviano entre 1932 y 1935, conflicto ...
Gabriela Dalla Corte
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Anagramas Rumbos y Sentidos de la Comunicación, 2018 Actualmente, se observa una disociación entre la actividad vernácula que desarrolla el estudiante en su vida social y la actividad del aula; teniendo en cuenta que en dicha vida social el ámbito virtual cobra cada vez más una mayor relevancia, se propone
Lirian Astrid Ciro
doaj +1 more source
, 2020 El objetivo de este proyecto es realizar una red social donde se puedan realizar diferentes actividades de ocio y/o ámbito profesional. Las principales funciones que tiene prevista esta aplicación son: - Buscar personas y grupos - Enviar mensajes entre personas - Seguir miembros y grupos - Publicar información, imágenes - Crear grupos.
openaire +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Uso de facebook y niveles de autoestima en adolescentes de secundaria
Revista de Psicología, 2019 La presente investigación tiene como objetivo identificar si existen diferencias en los niveles de autoestima a partir de las características del uso de Facebook en adolescentes de secundaria de una Institución Educativa de Arequipa. La investigación es
María del Carmen Tejada Rivera +1 more
doaj
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source