Results 131 to 140 of about 838,035 (305)

As Relações de Vizinhança nas Redes de Suporte Social dos Residentes no Bairro de Santiago em Aveiro [PDF]

, 2009
O presente estudo descreve o suporte social dos residentes do Bairro de Santiago em Aveiro. Numa perspectiva sistémica são analisadas as características estruturais, funcionais e contextuais da rede social pessoal do indivíduo, nomeadamente as relações ...
Caetano, Ana Paula Pereira, Guadalupe, Sonia (Coorientadora), Macedo, Esmeralda (Orientadora)   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A utilização dos elementos lúdicos e de dinâmicas Participativas nas práticas de ensino-aprendizagem junto à Agricultores familiares e urbanos [PDF]

, 2014
Trabalho apresentado no 31º SEURS - Seminário de Extensão Universitária da Região Sul, realizado em Florianópolis, SC, no período de 04 a 07 de agosto de 2013 - Universidade Federal de Santa Catarina.Recentemente, a extensão universitária no Brasil tem ...
Bertonha, Fernanda Maria, Costa, Tiago, Jung, Lígia, Messias, Samireille, Michellon, Ednaldo   +4 more
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Validation of the Lubben-6 Scale to measure social support networks among older adults in Chile

MedUNAB
Introduction. Assessing social support networks requires reliable and valid instruments, which are apparently nonexistent for older adults in Chile. The objective here is to adapt and further validate the Argentine version of the Lubben-6 Social Support ...
Emilio Moyano-Diaz, Mónica Edith Jorquera-Cox, Camila Marta Oda-Montecinos, Claudia Estrada-Goic   +3 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Social e em rede

Sinais de Cena, 2011
Social e em ...
Isabel Aleixo
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Educação na web: caracterização de perfis voltados ao ensino de Química no Instagram

Amazônia
O objetivo deste trabalho foi caracterizar os perfis na rede social Instagram voltados ao ensino de Química, nos quesitos: conteúdo das postagens, linguagem, identidade visual e interação dos seguidores.
Amanda Pereira de Sousa, Nairley Cardoso Sá Firmino, Diego Farias Firmino, Elton Patrick Barbano   +3 more
doaj   +1 more source

Alumni from the Polytechnic of Leiria: path & challenges [PDF]

, 2019
In this communication we will analyse the development of the Alumni Network of Polytechnic of Leiria, a higher public education institution in Portugal.
Beato, Isabel, Duarte, Ângela, Seco, Graça   +2 more
core