Results 161 to 170 of about 11,964,360 (256)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
REDE VIVA: A REALIDADE DA REDE DE ATENÇÃO À REABILITAÇÃO DO BUTANTÃ, SÃO PAULO - SP
, 2018 Introdução: Reabilitação é um conjunto de ações voltadas ao aumento das habilidades dos usuários com diminuição dos danos, incapacidades e deficiências; incluindo pessoas com doenças crônicas e degenerativas (FARO, 2004; LUSSI, 2006).
Schmitt, Ana Carolina Basso +4 more
core
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
, 2014 INTRODUÇÃO: O Programa é uma parceria entre a Universidade Federal do Paraná, com o Ministério da Saúde e as secretarias municipais de Paranaguá, Pontal do Paraná e Guaratuba - PR.
Signorelli, Marcos Claudio +6 more
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
REDE DE CUIDADOS EM PESSOAS COM DOENÇAS RESPIRATÓRIAS CRÔNICAS: UM ESTUDO DE REVISÃO
, 2018 INTRODUÇÃO: As Doenças Respiratórias Crônicas (DRC) devem ser atendidas as suas necessidades de acordo com o grau de complexidade em que se apresenta, este cuidado deve ser coordenado pela Atenção Básica, a qual atua com maior proximidade da família e da
Camelier, Aquiles Assun‚Ìo +7 more
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source