Results 161 to 170 of about 838,035 (305)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Redes sociales para mayores y/o mayores en las redes sociales

, 2011
La consolidación de la Web 2.0 y los medios sociales en nuestra sociedad coincide en el tiempo con el paulatino afianzamiento de un mercado emergente, el de las personas mayores. El objetivo de esta investigación es analizar, en el contexto de las redes sociales, cómo se gestiona la comunicación con el público maduro en España. Dos de los criterios que
Carretón-Ballester, Carmen, Ramos-Soler, Irene   +1 more
openaire   +1 more source

10 ANOS DE PESQUISA DA REVISTA BRASILEIRA DE INOVAÇÃO SOB A ÓTICA DA BIBLIOMETRIA E DA REDE SOCIAL

Administração: Ensino e Pesquisa, 2014
Este artigo explorou a produção científica da Revista Brasileira de Inovação no período de 2002 a 2011. A referida pesquisa se norteou numa pesquisa bibliométrica e de rede social, utilizando-se de estatística descritiva em 100 artigos identificados.
Henrique César Melo Ribeiro, Rosany Corrêa   +1 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Redes Sociais Integradas e difusão de informações: compreendendo a circulação da informação em social games

Em Questão, 2011
O trabalho busca apresentar uma reflexão de como a rede social dos social games é constituída a partir de uma discussão referente aos mecanismos de difusão de informações do jogo.
Rebeca Recuero Rebs, Gabriela da Silva Zago   +1 more
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Frailty and social network among older Brazilian adults: evidence from ELSI-Brazil. [PDF]

Rev Saude Publica
Marcelino KGS, Braga LS, Andrade FB, Giacomin KC, Lima-Costa MF, Torres JL.   +5 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Content validation of the nursing diagnosis "inadequate social support network". [PDF]

Rev Esc Enferm USP
França MS, Pontes CM, Lopes MVO, Mendes RCMG, Perrelli JGA, Morais SCRV, Linhares FMP.   +6 more
europepmc   +1 more source