Results 31 to 40 of about 275,246 (309)

Inovação pedagógica para a sustentabilidade da educação aberta e em rede [PDF]

, 2013
Desenvolvemos no presente artigo uma reflexão e análise sobre os processos que conduzem à promoção da inovação pedagógica nos cenários emergentes para a educação aberta e em rede. No quadro desta análise e a partir da distinção entre mediação tecnológica
Dias, Paulo
core  

Practices and consumption of Portuguese youth in digital environments [PDF]

, 2017
Na cultura juvenil, as lógicas de mobilidade, multiscreen e multitarefa permitem equacionar novas práticas mediáticas numa era de convergência das plataformas digitais e dos consumos em cross-media.
Amaral, Inês, Lopes, Paula, Quintas, Célia, Reis, Bruno   +3 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Making films in a Brazilian slum with children: a participant observation research [PDF]

, 2019
This article stands for innovative learning opportunities to social inclusion by film education. The theoretical model is a combined structure coming from approaches and projects of social inclusion through film education.
Juliana, Mirna, Pacheco, Raquel
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Contribuições para a discussão de um modelo de avaliação do impacto social [PDF]

, 2018
Atualmente, a questão do impacto social e os desafios colocados por um contexto de grandes mudanças à escala global, tem obrigado a repensar as respostas que as sociedades produzem para a sua própria coesão.
Barros, Valéria, Gouveia, Luis Borges
core  

Departing Reflections [PDF]

, 2016
Latin American ...
Hale, Charles R.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Modelo de Rede Social Virtual para Inclusão Digital e Social

RENOTE, 2018
O rápido avanço da tecnologia na sociedade não só proporciona o auxílio de diversas ferramentas para comunicação e inclusão social, como também cria maior necessidade de presença na mesma, um grande exemplo disso são as redes sociais virtuais que se tornaram parte da rotina de grande parcela da população. Neste contexto, tivemos como objetivo encontrar
Fernando Simões Arce, Yuri, Nunes Cerqueira, Fabio, Dutra Profirio de Souza, Hugo, Schimiguel, Juliano, Regina da Silva Rocha, Célia   +4 more
openaire   +3 more sources