Results 171 to 180 of about 40,114 (257)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Infodemic in COVID-19 and its relationship with stress, depression, and anxiety in the elderly. [PDF]

Rev Lat Am Enfermagem
Rodríguez-Campo VA, Valenzuela-Suazo SV, Bezerra-Cavalcante R, Sanhueza-Alvarado OI, Concha PDTJ, Vera-Calzaretta A, Palma-Novoa PM.   +6 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Targeting HIF2-PTHrP axis in kidney cancer: a paradigm shift in therapy? [PDF]

Clin Kidney J
Pella E, Jose Soler M.
europepmc   +1 more source

REDE OU REDES DE TEATROS

Indústrias Culturais, 2007
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

[Compassion fatigue in rural primary care: a silent challenge for professional caregiving]. [PDF]

Aten Primaria
Estrada-Araoz EG.
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

[Research trends on botulinum toxin A in bruxism: a bibliometric analysis]. [PDF]

Rev Med Inst Mex Seguro Soc
Vargas-Echeverría SL, Pech-Argüelles RC, Estrada-Rodríguez E.   +2 more
europepmc   +1 more source