Results 181 to 190 of about 371,571 (306)

Student Satisfaction in Social Media-Based Learning Environments: Development, Validation, and Psychometric Evaluation of the CuSAERS (Questionnaire of Satisfaction With Educational Activities Performed on Social Media). [PDF]

JMIR Med Educ
La Touche R, Reina-Varona Á, Grande-Alonso M, León-Hernández JV, Pardo-Montero J, Requejo-Salinas N, Ferrer-Peña R, Paris-Alemany A.   +7 more
europepmc   +1 more source

A promoção institucional de conhecimento colectivo em redes regionais e locais: considerações gerais

, 2000
A promoção institucional de conhecimento colectivo em redes regionais e locais: considerações ...
Sanz Menéndez, Luis
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Regionalization and regulation: impact on access to cancer treatment. [PDF]

Rev Saude Publica
Duarte LS, Shirassu MM, Ribeiro AG, Murta-Nascimento C, Fagundes MA, Luizaga CTM, Wünsch Filho V.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Network-level structural alterations distinguish persistent from remitted post-traumatic stress disorder: a morphometric covariance approach. [PDF]

Eur J Psychotraumatol
Lee S, Lee H, Joo Y, Suh C, Shim Y, Jin Y, Song H, Yoon S, Lyoo IK.   +8 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

[More than playing: The therapeutic value of play in comprehensive childcare from primary care]. [PDF]

Aten Primaria
González-Díaz A, Gómez-Salgado J, Suleiman-Martos N, Gómez-Urquiza JL.   +3 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Correction: Differences in metacognition between multiple sclerosis phenotypes: cognitive impairment and fatigue are key factors. [PDF]

Front Psychol
Coll-Martinez C, Salavedra-Pont J, Buxó M, Quintana E, Quiroga-Varela A, Robles-Cedeño R, Puig M, Álvarez-Bravo G, Ramió-Torrentà L, Gich J.   +9 more
europepmc   +1 more source