Results 241 to 250 of about 8,468,872 (333)
Advanced Science, EarlyView.CRISPR/Cas9 screening reveals PTPN2 as essential for ALK+ ALCL survival. PTPN2 regulates TFRC to promote PINK1‐PRKN mitophagy. Oral PTPN2 inhibitor ABBV‐CLS‐484 disrupts mitochondrial renewal and blocks TFRC‐mediated mitophagy to exert anti‐tumor activities, supporting clinical development for ALK+ ALCL.
Wei‐Ting Wang +11 more
wiley +1 more source
Mining social media data to inform public health policies: a sentiment analysis case study. [PDF]
Rev Panam Salud PublicaRussell SN, Rao-Graham L, McNaughton M.
europepmc +1 more source
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Advanced Science, EarlyView.This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou +14 more
wiley +1 more source
[The mediating role of social media addiction and sleep quality in the association between social media usage and depressive symptoms in university students]. [PDF]
Cad Saude PublicaRufino JV +3 more
europepmc +1 more source
La construcción del orden en el paso del antiguo régimen a la republica. Redes sociales e imaginario político del Nuevo Reino de Granada al espacio Grancolombiano [PDF]
, 2002 María Teresa Calderón +1 more
openalex
Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus
Advanced Science, EarlyView.This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu +9 more
wiley +1 more source
[Effectiveness of interventions to help mitigate the influence of social networks on anorexia and bulimia nervosa: a systematic review]. [PDF]
An Sist Sanit NavarLozano-Muñoz N +2 more
europepmc +1 more source
Trabajo Fin de Grado-Universidad Pontificia de Salamanca, Facultad de Educación ...
openaire +1 more source
Advanced Science, EarlyView.This study investigates the role of group 2 innate lymphoid cells (ILC2) in the choroid plexus (ChP) following traumatic brain injury (TBI). ILC2 accumulation alleviates immune infiltration, preserves hippocampal integrity, and improves sensory‐motor and memory functions.
Shiqi Gao +10 more
wiley +1 more source