Results 221 to 230 of about 182,782 (309)

[Society, communication and health: Moving through the Covid-19 pandemic and beyond]. [PDF]

Salud Colect
Rodríguez Zoya PG, Petracci M, Kaufman A.   +2 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Action-research in the development of a change management model to strengthen health interventions with an intercultural approach, Peru. [PDF]

Rev Peru Med Exp Salud Publica
Segovia-Meza G, Medina-Ibañez A, Bartolo-Marchena M, Monteza-Facho B.   +3 more
europepmc   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

[A comprehensive approach to achieving reverification of measles elimination in Venezuela, 2019-2023Abordagem integral para a reverificação da eliminação do sarampo na Venezuela, 2019-2023]. [PDF]

Rev Panam Salud Publica
Muro L, Castillo L, Rodríguez L, D'Angelo P, Porras N, García JM, Valderrama N, Rodríguez R, Villalobos N, Torres C, Villavicencio V.   +10 more
europepmc   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

[Social media as platforms for the visibility of gender-based violence during the COVID-19 pandemic in Colombia]. [PDF]

Salud Colect
Muñoz-Zapata DE, Osorio-Franco JM.
europepmc   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Hesitation towards the COVID-19 vaccine in the United States: a digital ethnographic study. [PDF]

Salud Colect
Vega RA.
europepmc   +1 more source

FICHAS PEDAGÓGICAS PARA LA EDUCACIÓN REMOTA DE EMERGENCIA EN ESCUELAS MULTIGRADO

, 2022
Herrera-Pavo MÁ, Patiño MGC, Fernández JRU.   +2 more
europepmc   +1 more source