Results 51 to 60 of about 193,265 (264)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Self-consistent simulation of the redistribution of co-circulating energetic particles induced by 2/1 tearing mode and 2/1 fishbone-like mode

Nuclear Fusion
The redistribution and loss of co-circulating energetic particles (co-CEPs) in the presence of 2/1 tearing mode (TM) and 2/1 fishbone-like mode (FLM) are self-consistently simulated using the global kinetic-MHD hybrid code M3D-K.
Baofeng Gao, Tao Liu, Qiang Guo, Ranran Tao, Han Qin, Ying Guo, Jingshan Pan   +6 more
doaj   +1 more source

REDISTRIBUTION AND HEALTH

American Journal of Public Health, 2005
In their evocative thought experiment, Woolf et al. demonstrate that reducing racial disparities might result in greater gains in life expectancy than investments in medical technology.1 In calculating reductions in mortality attributable to medical technology, the authors conservatively assumed that medical technology was responsible for 100% of the ...
openaire   +3 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Reciprocidade e Hierarquia

Revista de Antropologia, 1996
This paper suggests a re-evaluation of several analysis of exchange relations. It places special emphasis on M. Sahlins interpretation of gift exchange in Stone Age Economics, focusing on the complex of exchanges around "primitive" chiefs. It aims to set
Marcos Lanna
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Social Class and Child Welfare: Intertwining Issues of Redistribution and Recognition

Social Sciences, 2018
By the end of the 20th century, social class appeared to be an old-fashioned and outdated concept. Serious doubts were expressed about the theoretical and empirical relevance of social class in understanding inequalities in contemporary society. However,
Halvor Fauske, Bente Heggem Kojan, Anita Skårstad Storhaug   +2 more
doaj   +1 more source

CRITICAL ANALYSIS OF BANTU EDUCATION ACT OF 1953 AND IMPLICATIONS ON COVID-19 PANDEMIC IN BLACK SCHOOLS: A SOCIAL JUSTICE PERSPECTIVE

Social Sciences, Humanities and Education Journal, 2022
Corona Virus Disease (COVID-19) caught the world education systems by surprise and inflicted a deep-felt disruption in the previously disadvantaged black schools in South Africa.
Shuti Steph Khumalo
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source