Results 121 to 130 of about 7,720,158 (325)

Reduced-order modeling through machine learning and graph-theoretic approaches for brittle fracture applications

Computational materials science, 2019
Typically, thousands of computationally expensive micro-scale simulations of brittle crack propagation are needed to upscale lower length scale phenomena to the macro-continuum scale.
A. Hunter, B. Moore, M. Mudunuru, V. Chau, Roselyne B. Tchoua, C. Nyshadham, S. Karra, D. O’Malley, E. Rougier, H. Viswanathan, G. Srinivasan   +10 more
semanticscholar   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Reduced‐Order Modeling for Linearized Representations of Microphysical Process Rates

Journal of Advances in Modeling Earth Systems
Representing cloud microphysical processes in large scale atmospheric models is challenging because many processes depend on the details of the droplet size distribution (DSD, the spectrum of droplets with different sizes in a cloud).
K. D. Lamb, M. vanLier‐Walqui, S. Santos, H. Morrison   +3 more
doaj   +1 more source

Reduced-order modeling of parameterized multi-group diffusion k-eigenvalue problems

Annals of Nuclear Energy, 2019
In this paper, a group-wise Reduced-Order Model, based on a Proper Orthogonal Decomposition (POD) technique, is presented for parameterized multi-group diffusion k-eigenvalue problems.
P. German, J. Ragusa
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Dynamic Condensation-Based Reduction Method for Precise Broadband Frequency Analysis

Mathematics
In this paper, we propose a degree-of-freedom-based adaptive reduction method that ensures accuracy over a wide band. In the conventional dynamic condensation method, a single reduced model consisting of low-order modes is used throughout the analysis ...
Geomji Choi, Juhwan Lee, Seongmin Chang
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Reduced Order Modeling for Transonic Aeroservoelastic Control Law Development [PDF]

As aircraft become more flexible, aeroelastic considerations become increasingly important and complex, particularly for transonic flight where nonlinearities in the flow render linear analysis tools less effective.
Bartels, Robert E., Silva, Walter A., Stanford, Bret K., Waite, Josiah M.   +3 more
core   +1 more source