Results 121 to 130 of about 14,700,185 (245)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Koopman Reduced-Order Modeling with Confidence Bounds

SIAM Journal on Applied Dynamical Systems
Abstract. This paper introduces a reduced-order modeling technique based on Koopman operator theory that gives confidence bounds on the model’s predictions. It is based on a data-driven spectral decomposition of the Koopman operator. The reduced-order model is constructed using a finite number of Koopman eigenvalues and modes, while ...
Ryan Mohr, Maria Fonoberova, Igor Mezic
openaire   +2 more sources

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Efficient Dynamics: Reduced‐Order Modeling of the Time‐Dependent Schrödinger Equation

Advanced Physics Research
This work develops and rigorously analyzes reduced‐order modeling (ROM) techniques for the time‐dependent Schrödinger equation (TDSE), with the goal of efficiently capturing essential quantum dynamics at significantly reduced computational cost.
Kolade M. Owolabi
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Efficient POD reduced-order modeling for parametrized nonlinear PDE systems

, 2012
In this paper a model order reduction method for a nonlinear elliptic-parabolic system is developed. Systems of this type arise from mathematical models for lithium ion batteries.
Lass, Oliver
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Measurement of gas thermal properties using the parametric reduced-order modeling approach

, 2016
This paper deals with a thermal gas property micro-sensor. The proposed modeling approach of the sensor was based on reduced order modeling, in contrast to the traditional analytical modelling approach, which is the standard for this kind of sensors ...
Kalfas, Anestis, Pfau, Axel, Stingelin, Simon, Badarlis, Anastasios   +3 more
core   +1 more source

Reduced order modeling of blood perfusion in parametric multipatch liver lobules

Advanced Modeling and Simulation in Engineering Sciences
In this paper, we present a computationally efficient reduced order model for obtaining blood perfusion profiles within parametric functional units of the liver called ‘lobules’.
Ahsan Ali Siddiqui, Etienne Jessen, Stein K. F. Stoter, David Néron, Dominik Schillinger   +4 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source