Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
A class of reduced-order models in the theory of waves and stability. [PDF]
Proc Math Phys Eng Sci, 2016 Chapman CJ, Sorokin SV.
europepmc +1 more source
Rational Function-Based Approach for Integrating Tableting Reduced-Order Models with Upstream Unit Operations: Dry Granulation Case Study. [PDF]
Pharmaceuticals (Basel)Bachawala S +5 more
europepmc +1 more source
A priori estimation of memory effects in reduced-order models of nonlinear systems using the Mori-Zwanzig formalism. [PDF]
Proc Math Phys Eng Sci, 2017 Gouasmi A, Parish EJ, Duraisamy K.
europepmc +1 more source
Hospital Readmission After Traumatic Brain Injury Hospitalization in Community‐Dwelling Older Adults
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the risk of hospital readmission after an index hospitalization for TBI in older adults. Methods Using data from the Atherosclerosis Risk in Communities (ARIC) study, we used propensity score matching of individuals with an index TBI‐related hospitalization to individuals with (1) non‐TBI hospitalizations (primary analysis)
Rachel Thomas +7 more
wiley +1 more source
Stochastic reduced order models for inverse problems under uncertainty. [PDF]
Comput Methods Appl Mech Eng, 2015 Warner JE, Aquino W, Grigoriu MD.
europepmc +1 more source
Functional Connectivity Linked to Cognitive Recovery After Minor Stroke
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri +7 more
wiley +1 more source
Solving parameteric wave propagation models with domain decomposed reduced order methods [PDF]
, 2019 Cela Espín, José M. +3 more
core
Inverse problems in reduced order models of cardiovascular haemodynamics: aspects of data assimilation and heart rate variability. [PDF]
J R Soc Interface, 2017 Pant S +5 more
europepmc +1 more source