Results 51 to 60 of about 648,387 (311)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The Alcohol–High-Density Lipoprotein Athero-Protective Axis

Biomolecules, 2020
Ingestion of alcohol is associated with numerous changes in human energy metabolism, especially that of plasma lipids and lipoproteins. Regular moderate alcohol consumption is associated with reduced atherosclerotic cardiovascular disease (ASCVD), an ...
Corina Rosales, Baiba K. Gillard, Antonio M. Gotto, Henry J. Pownall   +3 more
doaj   +1 more source

Reducing the standard serving size of alcoholic beverages prompts reductions in alcohol consumption. [PDF]

, 2018
AIMS: To test whether reducing the standard serving size of alcoholic beverages would reduce voluntary alcohol consumption in a laboratory (study 1) and a real-world drinking environment (study 2).
Ally, Beard, Bloomfield, Brennan, Bush, Chiappetta, Collins, Dawkins, Ekholm, Flood, Goddard, Hollands, Hollands, Holmes, IBM Corporation, JASP Team, Marteau, Meier, Nichols, Norton, Pechey, Pechey, Pechey, Petrescu, Rehm, Rolls, Rolls, Rolls, Rouder, Saunders, Vocht, Zlatevska   +31 more
core   +1 more source

Acute Alcohol Consumption Reduces Uncertainty Choices

Journal of Addiction Medicine
Background and Aims: Drinking alcohol results in clear effects on decision-making in humans. Alcohol intake impairs information processing and executive function. However, the potential effects of alcohol on human uncertainty decision-making remain unknown.
Liu, Hao, Zhang, Yi, Li, Duo, Wang, Chun, Yuan, Ti-Fei, Jia, Yanbing, Wang, Fei   +6 more
openaire   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Are we making Inroads? A randomized controlled trial of a psychologist-supported, web-based, cognitive behavioral therapy intervention to reduce anxiety and hazardous alcohol use among emerging adults

EClinicalMedicine, 2021
Background: Anxiety and alcohol use disorders are common and disabling conditions that people typically endure for many years before accessing treatment.
Lexine A. Stapinski, Katrina Prior, Nicola C. Newton, Raaj Kishore Biswas, Erin Kelly, Mark Deady, Briana Lees, Maree Teesson, Andrew J. Baillie   +8 more
doaj   +1 more source

Varenicline decreases nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats [PDF]

, 2015
Background: Alcohol and nicotine are largely co-abused. Here, we investigated whether concurrent exposure to both addictive drugs influences each other's consumption and whether varenicline attenuates alcohol consumption in the presence of nicotine ...
Ciccocioppo, Roberto, Cippitelli, Andrea, Scuppa, Giulia, Toll, Lawrence, Ubaldi, Massimo   +4 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

How many alcohol-attributable deaths and hospital admissions could be prevented by alternative pricing and taxation policies? Modelling impacts on alcohol consumption, revenues and related harms in Canada

Health Promotion and Chronic Disease Prevention in Canada, 2020
IntroductionIn 2017, Canada increased alcohol excise taxes for the first time in over three decades. In this article, we describe a model to estimate various effects of additional tax and price policies that are predicted to improve health outcomes.
Stockwell, Tim, Churchill, Samuel, Sherk, Adam, Sorge, Justin, Gruenewald, Paul   +4 more
doaj   +1 more source