Results 51 to 60 of about 284,090 (311)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Weak evidence on nalmefene creates dilemmas for clinicians and poses questions for regulators and researchers [PDF]

, 2016
Background and aims Nalmefene has been approved in Europe for the treatment of alcohol dependence and subsequently recommended by the UK National Institute for Health and Care Excellence (NICE).
Raistrick, Duncan, Fitzgerald, Niamh, UK Centre for Tobacco and Alcohol Studies, McCambridge, Jim, Elders, Andrew, de Andrade, Marisa, De Andrade, Marisa; id_orcid, Heather, Nick, Angus, Kathryn   +8 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Intervention to reduce excessive alcohol consumption and improve comorbidity outcomes in hypertensive or depressed primary care patients: two parallel cluster randomized feasibility trials [PDF]

, 2014
Wilson, G. B. Wray, C. McGovern, R. Newbury-Birch, D. McColl, E. Crosland, A. Background Many primary care patients with raised blood pressure or depression drink potentially hazardous levels of alcohol.
Haining, Shona, Catherine Wray, Newbury-Birch, Dorothy; id_orcid, Newbury-Birch, Dorothy, Cassidy, Paul, Dave Tomson, Speed, Chris, Dorothy Newbury-Birch, Tomson, Dave, Wilson, Graeme, B., McColl, Elaine, Kaner, Eileen, Wray, Catherine, Crosland, Ann, Shona Haining, McGovern, Ruth, Denise Howel, Graeme B Wilson, Chris Speed, Wilson, Graeme, Howel, Denise, Paul Cassidy, Kaner, Eileen F. S., Elaine McColl, Eileen FS Kaner, Ruth McGovern, Ann Crosland   +26 more
core   +1 more source

The Alcohol–High-Density Lipoprotein Athero-Protective Axis

Biomolecules, 2020
Ingestion of alcohol is associated with numerous changes in human energy metabolism, especially that of plasma lipids and lipoproteins. Regular moderate alcohol consumption is associated with reduced atherosclerotic cardiovascular disease (ASCVD), an ...
Corina Rosales, Baiba K. Gillard, Antonio M. Gotto, Henry J. Pownall   +3 more
doaj   +1 more source

Are we making Inroads? A randomized controlled trial of a psychologist-supported, web-based, cognitive behavioral therapy intervention to reduce anxiety and hazardous alcohol use among emerging adults

EClinicalMedicine, 2021
Background: Anxiety and alcohol use disorders are common and disabling conditions that people typically endure for many years before accessing treatment.
Lexine A. Stapinski, Katrina Prior, Nicola C. Newton, Raaj Kishore Biswas, Erin Kelly, Mark Deady, Briana Lees, Maree Teesson, Andrew J. Baillie   +8 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Gender differences in changes in alcohol consumption achieved by free provision of non-alcoholic beverages: a secondary analysis of a randomized controlled trial

BMC Public Health
Background We recently demonstrated that a 12-week intervention consisting of the provision of free non-alcoholic beverages reduced alcohol consumption in excessive drinkers for 8 weeks after the intervention.
Shohei Dobashi, Kyoko Kawaida, Go Saito, Yukiko Owaki, Hisashi Yoshimoto   +4 more
doaj   +1 more source

How many alcohol-attributable deaths and hospital admissions could be prevented by alternative pricing and taxation policies? Modelling impacts on alcohol consumption, revenues and related harms in Canada

Health Promotion and Chronic Disease Prevention in Canada, 2020
IntroductionIn 2017, Canada increased alcohol excise taxes for the first time in over three decades. In this article, we describe a model to estimate various effects of additional tax and price policies that are predicted to improve health outcomes.
Stockwell, Tim, Churchill, Samuel, Sherk, Adam, Sorge, Justin, Gruenewald, Paul   +4 more
doaj   +1 more source