Results 111 to 120 of about 389,752 (273)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reversible secret image sharing scheme based on difference expansion

, 2013
碩士(t, n)門檻式機密影像分享技術是將機密影像分成n張無意義的分享影像並分配給n位參與者，其中任何超過t位參與者的群組，都能利用他們的分享影像還原機密影像。反之，則不能還原機密影像。同時，為降低分享影像的顯著性，可進一步藉由偽裝學(Steganography)技術，將分享影像藏入有意義的掩護影像中形成一張偽裝影像，來避免攻擊者的注意力與提供管理上的便利性。本文提出結合偽裝學技術的可逆機密影像分享技術，讓參與者在還原過程中，除了可以從偽裝影像中擷取機密影像外，還可以將偽裝影像回復成掩護影像 ...
劉崇安; Liu, Chong-An
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Liquid movement and electrical potential difference across in vitro lungs from fetal guinea pigs : responses to expansion and related factors

, 1998
Lungs from near-term fetal guinea pigs were supported in vitro; lung liquid production was measured by a dye dilution method using Blue Dextran 2000; electrical potential difference (PD) across fetal airways was measured using KCl-Agar salt bridges ...
Kojwang, David Ogweno
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Vapour pressure deficit affects crop water productivity, yield, and quality in tomatoes

Agricultural Water Management
A high atmospheric vapour pressure deficit (VPD) hinders calcium absorption in tomatoes (Solanum lycopersicum L.), which severely reduces tomato yield, crop water productivity (WPcrop), and quality.
Xuemei Yu, Luqi Niu, Yuhui Zhang, Zijian Xu, Junwei Zhang, Shuhui Zhang, Jianming Li   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Decreased chest mobility in children with spastic cerebral palsy

The Turkish Journal of Pediatrics, 2006
Consequences of neuromuscular impairment may lead to lung damage and reduced lung function in children with cerebral palsy (CP). The purpose of this study was to evaluate chest mobility by means of chest expansion (CE) measurements in patients ...
Murat Ersöz, Barin Selçuk, Ramazan Gündüz, Aydan Kurtaran, Müfit Akyüz   +4 more
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source