Results 41 to 50 of about 179,330 (266)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Implementation of a Prototype-Based Parkinson’s Disease Detection System Using a RISC-V Processor

Engineering Proceedings
In the wide range of human diseases, Parkinson’s disease (PD) has a high incidence, according to a recent survey by the World Health Organization (WHO). According to WHO records, this chronic disease has affected approximately 10 million people worldwide.
Krishna Dharavathu, Pavan Kumar Sankula, Uma Maheswari Vullanki, Subhan Khan Mohammad, Sai Priya Kesapatnapu, Sameer Shaik   +5 more
doaj   +1 more source

One Gate Scheme to Rule Them All: Introducing a Complex Yet Reduced Instruction Set for Quantum Computing [PDF]

, 2023
Jianxin Chen, Dawei Ding, Weiyuan Gong, Cupjin Huang, Qi Ye   +4 more
openalex   +1 more source

A novel reduced instruction set computer-communication processor design using field programmable gate array

International Journal of Reconfigurable and Embedded Systems (IJRES), 2023
In this paper, a novel reduced instruction set computer (RISC)- communication processor (RCP) has been designed with 32-bit operations which access 64-bit instruction format and implemented using field programmable gate array (FPGA). The design of the RISC processor is facilitated with communication operations like basic signals sine, cosine, and ...
Joseph Anthony Prathap, Sai Ramesh
openaire   +1 more source

Mira: A Framework for Static Performance Analysis

, 2017
The performance model of an application can pro- vide understanding about its runtime behavior on particular hardware. Such information can be analyzed by developers for performance tuning.
Meng, Kewen, Norris, Boyana
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Adapting the interior point method for the solution of LPs on serial, coarse grain parallel and massively parallel computers [PDF]

, 1990
In this paper we describe a unified scheme for implementing an interior point algorithm (IPM) over a range of computer architectures. In the inner iteration of the IPM a search direction is computed using Newton's method.
Andersen, J, Levkovitz, R, Mitra, G, Tamiz, M   +3 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Development of a novel MLS controller based on embedde d ARM

Journal of Measurement Science and Instrumentation, 2013
The controller plays an important rol e in microwave landing system（MLS） navigation equipment.The embedded advanced reduced-instruction-set-computing（RISC） machine（ARM） is introduced to de velop a new MLS controller based on the functional requirements.A
LI Xiang-jun1, QIN Bo2
doaj  

Protecting Private Data in the Cloud [PDF]

, 2012
Companies that process business critical and secret data are reluctant to use utility and cloud computing for the risk that their data gets stolen by rogue system administrators at the hosting company.
Aslam, Mudassar, Rasmusson, Lars
core   +1 more source