Results 171 to 180 of about 4,249,295 (316)

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Lineer olmayan schrödinger denkleminin enerji korumali yöntemle çözümü ve model indirgeme yönteminin uygulanmasi

open access: yes, 2013
Bu tezde lineer olmayan Schrödinger (NLS) denklemi enerji koruma özelliğine sahip ortalama vektör alanı (OVA) ile çözülmüştür. Ayrıca model indirgeme yöntemi olarak uygun dik ayrışım (UDA) yöntemi uygulanarak bir ve iki boyutlu NLS ve ikili NLS için elde
Akkoyunlu, Canan
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Development of a reduced-complexity climate model and applications on glacial-interglacial timescales

open access: yes, 2011
Global climate models are very valuable tools in climate sciences and are therefore used in many areas. The applications differ depending on the complexity of the components represented in the model. Three-dimensional physical models of the ocean and the
Ritz, Stefan
core  

Reduced model captures Mg(2+)-RNA interaction free energy of riboswitches. [PDF]

open access: yesBiophys J, 2014
Hayes RL   +5 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Vortex-induced vibration of catenary riser: reduced-order modeling and lock-in analysis using wake oscillator

open access: yes, 2009
A new reduced-order model capable of analyzing the vortex-induced vibration of catenary riser in the ocean current has been developed. This semi analytical-numerical approach is versatile and allows for a significant reduction in computational effort for
, KTP (Funder)   +5 more
core  

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