Results 181 to 190 of about 4,249,295 (316)

Sharp wave-ripple complexes in a reduced model of the hippocampal CA3-CA1 network of the macaque monkey [PDF]

BMC Neurosci, 2015
Ramirez-Villegas J, Logothetis N, Besserve M.   +2 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Neuromodulation impact on nonlinear firing behavior of a reduced model motoneuron with the active dendrite. [PDF]

Front Comput Neurosci, 2014
Kim H, Heckman CJ.
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

The prefrontal-striatal signatures of reduced model-based learning in depressed patients. [PDF]

Ann Gen Psychiatry
Wang X, Zhou X, Zhang D, Zhang Z, Gong Y, Feng Z, Hou JM.   +6 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Author Correction: Dynamical mechanisms of how an RNN keeps a beat, uncovered with a low-dimensional reduced model. [PDF]

Sci Rep
Zemlianova K, Bose A, Rinzel J.
europepmc   +1 more source

multiDE: a dimension reduced model based statistical method for differential expression analysis using RNA-sequencing data with multiple treatment conditions. [PDF]

BMC Bioinformatics, 2016
Kang G, Du L, Zhang H.
europepmc   +1 more source

Reduced Models

D2.6 Reduced Models (M24, BUL)From DSO/market scenarios studied in Task 2.5 provide distribution network models in CIM CGMES or PowerFactory form. Provide a detailed assessment of anticipated WP4 uses and iterate to ensure forward use.
openaire   +1 more source