Results 71 to 80 of about 15,278,073 (285)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Data‐Driven Reduced Order Modeling for Warm Rain Microphysics

Journal of Geophysical Research: Machine Learning and Computation
Accurately representing the formation of precipitation due to coalescence of cloud droplets remains a major challenge for atmospheric models. This study introduces and compares three data‐driven approaches for modeling the time evolution of droplet size ...
E. K. deJong, N. Gunawardena, J. E. Katona, H. Beydoun, D. Ghosh, P. Caldwell   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Reduced-Order Thermal Modeling for Photovoltaic Inverters Considering Mission Profile Dynamics

IEEE Open Journal of Power Electronics, 2020
Power devices are among the reliability-critical components in the Photovoltaic (PV) inverter, whose failures are normally related to the thermal stress. Therefore, thermal modeling is required for estimating the thermal stress of the power devices under
Ariya Sangwongwanich, Huai Wang, Frede Blaabjerg   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Reduced Order Modeling of Composite Laminates Through Solid-Shell Coupling

Journal of Aerospace Technology and Management, 2017
Composite laminates display a complex mechanical behavior due to their microstructure, with a through-thickness variation of the displacement and stress fields that depends on the fiber orientation in each layer. Aiming to develop reduced-order numerical
Gigliola Salerno, Stefano Mariani, Alberto Corigliano   +2 more
doaj  

Exploring Advectable Latent Representations for Droplet Size Distributions With Physics‐Informed Autoencoders

Journal of Advances in Modeling Earth Systems
Investigating the role of clouds and precipitation in the Earth system necessitates microphysical schemes capable of accurately describing the evolution of hydrometeor particle size distribution (PSD), while maintaining low computational costs ...
Kang‐En Huang, Minghuai Wang, Daniel Rosenfeld, Yannian Zhu   +3 more
doaj   +1 more source