Results 81 to 90 of about 15,278,073 (285)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Autoencoders for discovering manifold dimension and coordinates in data from complex dynamical systems

Machine Learning: Science and Technology
While many phenomena in physics and engineering are formally high-dimensional, their long-time dynamics often live on a lower-dimensional manifold. The present work introduces an autoencoder framework that combines implicit regularization with internal ...
Kevin Zeng, Carlos E Pérez De Jesús, Andrew J Fox, Michael D Graham   +3 more
doaj   +1 more source

Neuro-Fuzzy Network-Based Reduced-Order Modeling of Transonic Aileron Buzz

Aerospace, 2020
In the present work, a reduced-order modeling (ROM) framework based on a recurrent neuro-fuzzy model (NFM) that is serial connected with a multilayer perceptron (MLP) neural network is applied for the computation of transonic aileron buzz.
Rebecca Zahn, Christian Breitsamter
doaj   +1 more source

KROM: Kernelized Reduced Order Modeling

CoRR
We propose KROM, a kernel-based reduced-order framework for fast solution of nonlinear partial differential equations. KROM formulates PDE solution as a minimum-norm (Gaussian-process) recovery problem in an RKHS, and accelerates the resulting kernel solves by sparsifying the precision matrix via sparse Cholesky factorization.
Aras Bacho, Jonghyeon Lee, Houman Owhadi
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Reduced Order Modeling of a Shipboard Power System [PDF]

, 2013
Reduced-order average-value models form the basis of a computationally efficient approach for studying shipboard power systems. As a result of neglecting fast states, this approach generally involves solving a set of differential algebraic equations ...
Fu, Y., Lee, Y., Mohammadpour, H.A., Langston, J., Dougal, R.A., Faruque, M.O., Ouroua, A., Shoder, K., Abdelwahed, S., Santi, E., Asrari, A., et. al., Crider, J.   +12 more
core   +1 more source

LiCROM: Linear-Subspace Continuous Reduced Order Modeling with Neural Fields [PDF]

, 2023
Linear reduced-order modeling (ROM) simplifies complex simulations by approximating the behavior of a system using a simplified kinematic representation.
Grinspun, Eitan, Wang, Zhecheng, Chang, Yue, Chen, Peter Yichen, Carlberg, Kevin, Chiaramonte, Maurizio M.   +5 more
core  

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Controlling quantum many-body systems using reduced-order modeling

Physical Review Research
Quantum many-body control is among the most challenging problems in quantum science due to its outstanding computational complexity in a general case. We propose an efficient approach to a class of many-body quantum control problems, where time-dependent
I. A. Luchnikov, M. A. Gavreev, A. K. Fedorov   +2 more
doaj   +1 more source

Applications of Reduced Order and Surrogate Modeling in Structural Dynamics

, 2019
Despite recent advances in computational science, the adoption of computationally intensive, high-fidelity simulation models remains a challenge for many structural dynamics applications, especially those within the domain of uncertainty quantification ...
Alexandros A. Taflanidis, Zhang, Jize, Taflanidis, Alexandros A., Jize Zhang, Dimitris Patsialis, Patsialis, Dimitris   +5 more
core   +1 more source