Results 71 to 80 of about 19,863,493 (281)

Evaluation of Errors in Reduced Order Modeling

Transactions of the Society of Instrument and Control Engineers, 1999
The purpose of the paper is to make a comparison between the equation errors and the output errors which are used as criteria for measuring modeling errors in system identification. In many practical situations real systems have high system orders which are often unknown, and reduced order models are used for estimating the parameters of the systems ...
IKEDA, Fujio, WATANABE, Atsushi, KAWATA, Seiichi   +2 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Reduced-Order Modeling of the Fluidic Pinball [PDF]

, 2019
The fluidic pinball is a geometrically simple flow configuration with three rotating cylinders on the vertex of an equilateral triangle. Yet, it remains physically rich enough to host a range of interacting frequencies and to allow testing of control laws within minutes on a laptop.
Pastur, Luc, Deng, Nan, Morzyński, Marek, Noack, Bernd R.   +3 more
openaire   +4 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

On the Interpolation of Reduced-Order Models

, 2018
A parametric model-order reduction method based on interpolation of reduced-order models, namely the pole-matching method, is proposed for linear systems in the frequency domain.
Peter Benner, Lihong Feng, Yao Yue
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Reduced Order Modeling Methods for Turret - Gun System [PDF]

, 1990
Reduced-order modeling techniques are used to design lower order robust controllers for a turret-gun system. The balance-truncation, Routh approximation, and L. Litz\u27s (1980) modal techniques are used to derive the models. A critical comparison of the
Rao, Vittal S., Norman P. Coleman, S. Vittal Rao, Coleman, Norman P.   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source