Results 111 to 120 of about 664,134 (330)

Medium-Sized Ring Expansion Strategies: Enhancing Small-Molecule Library Development

Molecules
The construction of a small molecule library that includes compounds with medium-sized rings is increasingly essential in drug discovery. These compounds are essential for identifying novel therapeutic agents capable of targeting “undruggable” targets ...
Hwiyeong Lee, Jonghoon Kim, Minseob Koh
doaj   +1 more source

A Study of Intermediate Frequency Magnetic Pulse Device Applied to Reduce in Residual Stress in Thin-walled Bearing Rings (Jackie (1981) reported)

Chemical Engineering Transactions, 2015
Residual stress will be in the thin wall bearing rings after they are machined. The residual stress may change the organizational performance and dimension of the bearing rings, and reduce the rate of qualified products resulting in loss of product ...
X.M. Li
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Orthogonal Completions of Reduced Rings with Respect to Abian Order [PDF]

, 1980
K. Razi Naqvi
openalex   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Research on the Impact of Labyrinth Seal Ring Tooth Profile on the Pressure Pulsation of Leakage Chambers in High-Speed Centrifugal Pumps

Lubricants
The gap seal ring is a critical component in high-speed centrifugal pumps. The leakage rate and performance of the pump are sensitive to variation in seal ring parameters.
Guodong Zhao, Jiahao Xu, Jie Lian, Yanpi Lin, Zuchao Zhu   +4 more
doaj   +1 more source

Big tight closure test elements for some non-reduced excellent rings [PDF]

, 2011
Rodney Y. Sharp
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Some Results on AWN-injective Rings

NTU Journal of Pure Sciences
A concept of AWN-injective ring is defined by [1], that is, for any   there exists  and an Y-sub module  of  (  is aright -module) such that  and  as left S-module with S=End(u ). If  is AWN-injective module, then we call  aright AWN-injective ring.
Hazim Talat Hazim, Shaimaa Ahmad , Raida Mahmood   +2 more
doaj   +1 more source