Results 131 to 140 of about 330,401 (264)

The efficacy of tamsulosin 0.4 mg when tamsulosin 0.2 mg is insufficient for benign prostatic hyperplasia in Korean patients. [PDF]

Investig Clin Urol
Chung Y, Jeong SJ, Song SH, Hong SK.
europepmc   +1 more source

Uncovering Cystic Fibrosis Carrier: Insights From a Heterozygous CFTR‐F508del Rabbit Model

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder frequently associated with impaired mucociliary clearance and bacterial infection. Individuals carrying a single cystic fibrosis transmembrane conductance regulator (CFTR) mutation exhibit partial CFTR dysfunction and are increasingly recognized as being at risk ...
Do‐Yeon Cho, Alexis E. McFeely, Daniel Skinner, Shaoyan Zhang, Justin Hedvat, Weslee Ping‐ay, Daniel M. Beswick, Justin H. Turner, Bradford A. Woodworth, Jie Xu   +9 more
wiley   +1 more source

Structural Insights Into CO2 Transport Pathways in a W‐Formate Dehydrogenase: Structural Basis for CO2 Reduction

Angewandte Chemie, EarlyView.
Integrated structural analysis of N. vulgaris formate dehydrogenase AB, an enzyme with applications in climate change mitigation, is reported. The substrate/product diffusion pathways were fully mapped, and a retention site was identified that transiently holds substrates and has a key role in CO2‐reducing activity.
Guilherme Vilela‐Alves, Rita Rebelo Manuel, Guilherme Martins, Philippe Carpentier, Agata Raczyńska, Maciej Szaleniec, Inês A. Cardoso Pereira, Maria João Romão, Cristiano Mota   +8 more
wiley   +2 more sources

5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes. [PDF]

NeuroSci
Rodriguez-Cerdeira C.
europepmc   +1 more source

Mesoporous Silica Nanoparticles With Customized Drug Ratio/Loading for Effective Treatment of Gemcitabine‐Resistant Pancreatic Tumors

Advanced NanoBiomed Research, EarlyView.
Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq, Sudip Kumar Dam, Doaha Awad, Punnya Anil Kumar Jeeja, Farzana Ferdous, Juan L. Vivero‐Escoto   +5 more
wiley   +1 more source

Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors

Angewandte Chemie, EarlyView.
We report a photoenzymatic hydroalkylation that enables streamlined, stereocontrolled access to aryl glutarimide precursors relevant to targeted protein degradation. Engineered flavin‐dependent “ene”‐reductases provide broad scope and high enantioselectivity through a distinct electron transfer–enantioselective proton transfer pathway.
Zhi Xu, Prasun Mukherjee, Steven Gossert, Stephen Thomas, Vasil H. Vasilev, Eric R. Welin, Yichen Tan, Shane M. McKenna, Megan A. Emmanuel, Todd K. Hyster   +9 more
wiley   +2 more sources

Cardiovascular safety of 5α-reductase inhibitors in people with benign prostatic hyperplasia and type 2 diabetes: a propensity score-matched analysis. [PDF]

Eur Heart J Cardiovasc Pharmacother
Tu H, Ju C, McGurnaghan SJ, Blackbourn LAK, Scottish Diabetes Research Network Epidemiology Group , Pearson E, Wei L, Andrew R.   +7 more
europepmc   +1 more source

Comparative analysis of rumen metagenomes with dietary supplementation of 3-nitrooxypropanol revealed divergent modes of action in hydrogen metabolism and reductant pathways between beef and dairy cattle. [PDF]

Microbiome
Choi Y, Zhou M, Oba M, Romero-Pérez A, Beauchemin KA, Duval S, Kindermann M, Guan LL.   +7 more
europepmc   +1 more source

Harboring potential of enzymatic antioxidants in sweet potato [<i>Ipomoea batatas</i> (L.) Lam.] nodal cultures under <i>in vitro</i> NaCl-mediated salinity stress conditions. [PDF]

Front Plant Sci
Mishra A, Dasgupta M, Mohanty S, Tripathy P, Krishnappa HG, Singh S, Chauhan VBS, Arutselvan R, Sahoo BB, Sahoo MR.   +9 more
europepmc   +1 more source

Antioxidative enzymes as markers for the selection of advanced sweet potato breeding lines under <i>in vitro</i> osmotic stress conditions. [PDF]

Front Plant Sci
Mishra A, Tripathy P, Krishnappa HG, Dasgupta M, Mohanty S, Singh S, Chauhan VBS, Arutselvan R, Sahoo BB, Sahoo MR.   +9 more
europepmc   +1 more source