Results 111 to 120 of about 623,822 (311)

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

Spectroelectrochemical Elucidation of the Kinetics of Two Closely Spaced Electron Transfers [PDF]

, 2012
The use of spectroelectrochemistry to facilitate the analysis of an EE mechanism was reported in this work. Using a set of spectra as a function of potential, the spectra of all three oxidation states were determined using evolving window factor analysis.
Keesey, Robert L., Ryan, Michael D.
core   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

A functional description of CymA, an electron-transfer hub supporting anaerobic respiratory flexibility in Shewanella [PDF]

, 2012
CymA (tetrahaem cytochrome c) is a member of the NapC/NirT family of quinol dehydrogenases. Essential for the anaerobic respiratory flexibility of shewanellae, CymA transfers electrons from menaquinol to various dedicated systems for the reduction of ...
Butt, Julea N., Bye, Jordan, Cheesman, Myles R., Fredrickson, Jim, Jeuken, Lars J. C., Lowe, Thomas G., Marritt, Sophie J., McMillan, Duncan G. G., Richardson, David J., Shi, Liang, Zachara, John   +10 more
core   +1 more source

Water Permeates and Plasticizes Amorphous Carbon Dots: Unraveling the Inner Accessibility of the Nanoparticles by Glass Transition Studies

Advanced Materials, EarlyView.
The water permeability of amorphous carbon dots (CDs) is demonstrated by investigating their plasticization. Novel polyamide‐based and amorphous nanoparticles are synthesized by controlling their inner packing density. Water plasticization is evidenced by the decrease of the CDs glass transition temperature with increasing the hydration degree.
Elisa Sturabotti, Valerio Di Lisio, Lucia Cardo, Alessandro Camilli, Estela Moretón Alfonsín, Daniele Cangialosi, Amaia Iturrospe Ibarra, Arantxa Arbe, Maurizio Prato   +8 more
wiley   +1 more source

Nitrate and nitrite reductase activities of Mycobacterium avium

International Journal of Mycobacteriology, 2018
Background: In spite of the fact that the standard test for nitrate reductase activity is negative for Mycobacterium avium, it can grow in a defined minimal medium with either nitrate (NO3) or nitrite (NO2) as sole nitrogen sources.
Nitin S Butala, Joseph Oliver Falkinham
doaj   +1 more source

Bacterial nitrate assimilation: gene distribution and regulation [PDF]

, 2011
In the context of the global nitrogen cycle, the importance of inorganic nitrate for the nutrition and growth of marine and freshwater autotrophic phytoplankton has long been recognized.
Andrew J. Gates, Assumpção, Caballero, Cabello, Chai, Chen, Conrado Moreno-Vivián, David J. Richardson, Flores, Forchhammer, Forchhammer, Gates, Gutierrez, Ishida, Kayumov, Koropatkin, Leigh, Li, Lin, Lledó, Llácer, M. Dolores Roldán, Moreno-Vivián, Nakano, Ogawa, Ohashi, Pawlowski, Paz-Yepes, Pino, Puerta-Fernández, Ramos, Richardson, Sanders, Shao, Shu, Shu, Stuart J. Ferguson, Swanson, Szeto, Toukdarian, Víctor M. Luque-Almagro, Weiss, Weiss, Wray, Wu   +44 more
core   +1 more source

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Dihydropteridine Reductase

Pteridines, 1993
During the past decade numerous advances have been made in understanding the structure, mechanism and clinical properties of dihydropteridine reductase.
Whiteley John M., Varughesej Kottayil I., Xuong Nguyen H., Matthews David A., Grimshaw Charles E.   +4 more
doaj   +1 more source

5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis

Reproductive Biology and Endocrinology, 2017
Background 5α-reductase activity might be important during the development of polycystic ovary syndrome (PCOS). However, the changes of 5α-reductase activity in PCOS subjects and the relationship between 5α-reductase activity and body mass index (BMI ...
Chuyan Wu, Ke Wei, Zhongli Jiang
doaj   +1 more source