Results 31 to 40 of about 854,050 (403)

Aldose Reductase Inhibitors [PDF]

Journal of Enzyme Inhibition, 2001
Aldose reductase ([EC1.1.1.21]: AR) acts on the first step of the polyol metabolic pathway to catalyze the reduction of glucose to sorbitol with NADPH as a coenzyme. Hyperactivity of the pathway in individuals with high blood glucose level is closely related to the onset or progression of diabetic complications.
M, Oka, N, Kato
openaire   +2 more sources

Structure and evolution of chlorate reduction composite transposons. [PDF]

, 2013
UnlabelledThe genes for chlorate reduction in six bacterial strains were analyzed in order to gain insight into the metabolism. A newly isolated chlorate-reducing bacterium (Shewanella algae ACDC) and three previously isolated strains (Ideonella ...
Clark, Iain C, Coates, John D, Engelbrektson, Anna, Melnyk, Ryan A   +3 more
core   +2 more sources

The mutualistic fungus Piriformospora indica protects barley roots from a loss of antioxidant capacity caused by the necrotrophic pathogen Fusarium culmorum [PDF]

, 2013
Fusarium culmorum causes root rot in barley (Hordeum vulgare), resulting in severely reduced plant growth and yield. Pretreatment of roots with chlamydospores of the mutualistic root-colonizing basidiomycete Piriformospora indica (Agaricomycotina ...
Balázs Barna, Borbála D. Harrach, Dolatabadi H. K., Halliwell B., Helmut Baltruschat, József Fodor, Karl-Heinz Kogel, Varma A.   +7 more
core   +1 more source

The flavoheme reductase Ncb5or protects cells against endoplasmic reticulum stress-induced lipotoxicity[S]

Journal of Lipid Research, 2010
NCB5OR is a novel flavoheme reductase with a cytochrome b5-like domain at the N-terminus and a cytochrome b5 reductase-like domain at the C terminus. Ncb5or knock-out mice develop insulin deficient diabetes and loss of white adipose tissue.
Yongzhao Zhang, Kevin Larade, Zhi-gang Jiang, Susumu Ito, WenFang Wang, Hao Zhu, H. Franklin Bunn   +6 more
doaj   +1 more source

The NADPH-Dependent thioredoxin reductase C-2-Cys peroxiredoxin redox system modulates the activity of thioredoxin x in arabidopsis chloroplasts [PDF]

, 2018
The chloroplast redox network is composed of a complex set of thioredoxins (Trxs), reduced by ferredoxin (Fdx) via a Fdx-dependent Trx reductase (FTR), and an NADPH-dependent Trx reductase with a joint Trx domain, NTRC, which efficiently reduces 2-Cys ...
Cejudo Fernández, Francisco Javier, Ojeda Servián, Valle, Pérez Ruiz, Juan Manuel   +2 more
core   +1 more source

Methylenetetrahydrofolate reductase and psychiatric diseases

Translational Psychiatry, 2018
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for the critical process of one-carbon metabolism involving folate and homocysteine metabolisms. It is known that some polymorphism of MTHFR would result in reduction of MTHFR enzyme activity as
Lin Wan, Yuhong Li, Zhengrong Zhang, Zuoli Sun, Yi He, Rena Li   +5 more
semanticscholar   +1 more source

Selenoprotein gene nomenclature [PDF]

, 2016
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis.
Arn\ue9r, Elias S., Berry, Marla J., Bruford, Elspeth A., Burk, Raymond F., Carlson, Bradley A., Castellano, Sergi, Chavatte, Laurent, Conrad, Marcus, Copeland, Paul R., Diamond, Alan M., Driscoll, Donna M., Ferreiro, Ana, Floh\ue9, Leopold, Gladyshev, Vadim N, Green, Fiona R., Guig\uf3, Roderic, Handy, Diane E., Hatfield, Dolph L., Hesketh, John, Hoffmann, Peter R., Holmgren, Arne, Hondal, Robert J., Howard, Michael T., Huang, Kaixun, K\uf6hrle, Josef, Kim, Hwa Young, Kim, Ick Young, Krol, Alain, Kryukov, Gregory V., Lee, Byeong Jae, Lee, Byung Cheon, Lei, Xin Gen, Lescure, Alain, Liu, Qiong, Lobanov, Alexei V., Loscalzo, Joseph, Maiorino, Matilde, Mariotti, Marco, Prabhu, K. Sandeep, Rayman, Margaret P., Regina, Brigelius Floh\ue9, Rozovsky, Sharon, Salinas, Gustavo, Schmidt, Edward E., Schomburg, Lutz, Schweizer, Ulrich, Simonovi\u107, Miljan, Sunde, Roger A., Tsuji, Petra A., Tweedie, Susan, Ursini, Fulvio, Whanger, Philip D., Zhang, Yan   +52 more
core   +3 more sources

Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression. [PDF]

, 2016
Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is a cytoprotective enzyme upregulated in the vasculature by increased flow and inflammatory stimuli.
Azuma, Junya, Dalman, Ronald L, Deng, Alicia C, Hsu, Mark, Kalish, Flora, Kayama, Yosuke, Maegdefessel, Lars, Morisawa, Takeshi, Spin, Joshua M, Stevenson, David K, Tsao, Philip S, Wallenstein, Matthew B, Wong, Ronald J, Zhao, Hui   +13 more
core   +10 more sources

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

Nature Communications, 2018
Statins are inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis, and have been clinically used to treat cardiovascular disease.
Shi-You Jiang, Hui Li, Jingjie Tang, Jie Wang, Jie Luo, Bingqian Liu, Jin-Kai Wang, Xiong-Jie Shi, Hai-Wei Cui, Jie Tang, Fan Yang, Wei Qi, Wen-Wei Qiu, B. Song   +13 more
semanticscholar   +1 more source

Dyslipidemic drugs in metabolic syndrome

Indian Journal of Endocrinology and Metabolism, 2013
Introduction: Metabolic syndrome predisposes to diabetes and atherosclerotic vascular disease. Statins reduce cardiovascular events, so all metabolic syndrome patients should be evaluated for dyslipidemia.
Sheelu S Siddiqi, Misbahuddin, Farida Ahmad, Syed Z Rahman, Asad U Khan   +4 more
doaj   +1 more source