Results 221 to 230 of about 9,799,480 (312)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

US Retina Specialists' Preferences for Geographic Atrophy Treatment. [PDF]

Clin Ophthalmol
Csaky K, Pepio AM, Thomas C, Levitan B, Garg S, Tran N, Irony I, Krucien N, Doldos A, Whitty JA.   +9 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Therapeutic strategy for incarcerated obturator hernia: laparoscopic surgery after ultrasound-guided noninvasive manual reduction. [PDF]

Front Surg
Shioi Y, Kawashima T, Kumagai H, Ito K, Tsushima M, Fujii Y.   +5 more
europepmc   +1 more source

A Comparison of Outcomes and Complications Between Closed Reduction and Open Reduction of Mandibular Condylar and Subcondylar Fractures. [PDF]

Laryngoscope Investig Otolaryngol
Africa RE, McKinnon BJ, Ranasinghe VJ.
europepmc   +1 more source

Eustachian Tuboplasty as an Adjunct Treatment to Concurrent Tympanostomy Tube Insertion for Otitis Media With Effusion: A Systematic Review. [PDF]

Laryngoscope Investig Otolaryngol
Geneau H, Lewis HC, Holmes SP.
europepmc   +1 more source

Rainfall deficit reduces biodiversity and destabilizes a saline-soil plant community. [PDF]

Sci Adv
Wang X, Yan L, Jiang M, Wang Z, Sun B, Li H, Shi J, Liu W, Han G, Xia J.   +9 more
europepmc   +1 more source

Pharmacokinetics of 5-Fluorouracil in Patients Treated With Capecitabine Carrying the c.1236G>A <i>DPYD</i> Variant Allele. [PDF]

JCO Precis Oncol
Heersche N, Knikman JE, Deenen MJ, Rosing H, van Schaik RHN, Beijnen JH, Schellens JHM, Gelderblom H, Guchelaar HJ, Swen JJ, Cats A, Mathijssen RHJ, Jacobs BAW.   +12 more
europepmc   +1 more source