Results 31 to 40 of about 119,452 (240)
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
EnergiesLow thermal conductivity of phase change materials (PCMs) remains a major limitation in the design of efficient thermal energy storage systems. Enhancing the thermal performance of PCM storage units is therefore a critical design consideration.
Amr Owes Elsayed
doaj +1 more source
Properties and formation mechanism of rings during rotary kiln reduction of low-grade iron ore
工程科学学报, 2018 To ease the imbalance between the supply and demand for iron ore in the ferrous industry of China, a low-temperature reduction process via an ore-coal composite method was developed to recover iron from low-grade iron-ore resources (about 30%).
HUANG Zhu-cheng +4 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Case Studies in Thermal EngineeringIn this study, a numerical analysis was performed to investigate how the aspect ratio of flat tubes in a double-tube latent thermal energy storage system affects the melting behavior and thermal transfer properties of N-eicosane.
Gwan Gyu Kim +5 more
doaj +1 more source
A STUDY INTO ICE BUILD-UP AND MELTING ON VERTICAL COOLED PIPES
Holodilʹnaâ Tehnika i Tehnologiâ, 2016 The use of cold accumulators based on the principle of ice build up on the cooled surfaces during off-peak periods and ice melting during on-peak periods is an effective method of electricity bills reduction. Within comparatively short periods of on-peak
Y. Zasiadko +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source