Results 71 to 80 of about 119,452 (240)

Development and properties study of a composition of polypropylene with polyethylene terephthalate [PDF]

E3S Web of Conferences
The article presents the results of a study on the technological and thermal properties of compositions based on waste polyethylene terephthalate (PET) and polypropylene (PP), such as melt flow rate, melting point, heat resistance according to the Vicat ...
Mukhiddinov Bakhodir, Tilavova Lola, Sharipov San’at, Akhtamov Dilshod   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Analysis of NePCM melting flow inside a trapezoidal enclosure with hot cylinders: Effects of hot cylinders configuration and slope angle

Case Studies in Thermal Engineering
Hot cylinders within the cavity can find diverse thermal applications, ranging from electronic devices and heat exchangers to solar systems, nuclear reactors, and the thermal design of passive cooling systems.
Nidhal Ben Khedher, S.A.M. Mehryan, Mohammad Shahabadi, Amira M. Hussin, Abed Saif Alghawli, Mohsen Sharifpur   +5 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Determination of Major and Minor Components in High-Cr Red Mud by X-ray Fluorescence Spectrometry with Fusion Sample Preparation

Yankuang ceshi, 2014
Cr and other valuable metals are enriched in red mud (Cr2O3: 3%-30%) after high-Cr red clay type Al-Fe composite ores are comprehensively utilized by sodium reduction roasting-magnetic separation-leaching.
ZHU Zhong-ping, ZENG Jing-hua, WANG Chang-gen, Lü Li-chao   +3 more
doaj   +2 more sources

INVESTIGATION OF PROCESS FOR MANUFACTURING MOLYBDENUM-CONTAINING PRELIMINARY ALLOY USING OUT-OF-FURNACE METALLURGY METHOD

Наука и техника, 2012
The paper considers some technologies pertaining to manufacturing ferromolybdenum preliminary alloy. It has been shown that the reduction melting method based on the aluminium thermal metallurgy presents practical interest for manufacturing the given ...
A. G. Slutsky, A. S. Kalinichenko, V. A. Sheinert   +2 more
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source