Results 91 to 100 of about 6,804,387 (286)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Cifra: МашиностроениеИзложен метод упрощения процедуры решения систем нелинейных алгебраических и трансцендентных уравнений, описывающих нестационарное состояние газостатических подшипников.
Коднянко В.А. +2 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Dimension Reduction Methods [PDF]
, 2011 One characteristic of computational statistics is the processing of enormous amounts of data. It is now possible to analyze large amounts of high-dimensional data through the use of high-performance contemporary computers. In general, however, several problems occur when the number of dimensions becomes high.
openaire +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Component model reduction via the projection and assembly method [PDF]
The problem of acquiring a simple but sufficiently accurate model of a dynamic system is made more difficult when the dynamic system of interest is a multibody system comprised of several components.
Bernard, Douglas E.
core +1 more source
International Journal for Computational Civil and Structural Engineering, 2017 At present, as is known, there are many methods of reduction of computational dimension of problems of structural analysis within finite element method (FEM), including the reduction of the dimensions of the mass matrix and the stiffness matrix of the ...
Alexander M. Belostotsky +2 more
doaj +1 more source