Results 151 to 160 of about 776,097 (338)

Rethinking medical education through systems biology to address complexity. [PDF]

NPJ Syst Biol Appl
David L, Gourraud PA, Lamirault G, Lemarchand P.   +3 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

DISCUSSION: PEACOCKE'S “REDUCTIONISM”

Zygon, 1976
doaj   +2 more sources

Physical explanations in evolutionary biology. [PDF]

Hist Philos Life Sci
Hermida M, Ladyman J.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Off-label use of medications in psychiatry: the need and the caveats. [PDF]

World Psychiatry
Vieta E.
europepmc   +1 more source

Potential Dependence of Coupling vs. Reduction in the Reaction between Benzyl Halides and Anion Radicals. [PDF]

, 1989
René Fuhlendorff, Donatella Occhialini, Steen Uttrup Pedersen, Henning Lund, Lija Tekenbergs-Hjelte, Kristina Ohlson   +5 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Challenges in the Immune System: Mesoscale and Mesoregime Complexity. [PDF]

Cancer Innov
Ren Y, Wu AG, Shi Y, Ping YF, Li JH, Bian XW.   +5 more
europepmc   +1 more source

Model-Order Reduction of the Full-Wave Partial-Element Equivalent-Circuit (PEEC) Method Based on a Modal Approach

Philipp Herwigk, Marco Leone
openalex   +1 more source