Results 151 to 160 of about 725,259 (219)

Does Resistance Training Provide Benefits that Are Comparable to Aerobic Exercise in Hypertension? [PDF]

Curr Hypertens Rep
Tanaka H, Ferrari R.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Systematic Review of Herbal Medicines in the Management of Diabetes: Efficacy, Toxicological Profiles, and Clinical Safety Considerations. [PDF]

Cureus
Nampalliwar A, Singh NK, Kher M, Sasane PU, Sinha CP, Dixit UK.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A city-scale optimization framework for biomass-to-clean-energy transitions: The KAMPALA-TIMES model. [PDF]

iScience
Kimuli I, Kirabira JB, Mujjuni F.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Long-Term Reductions in Headache Frequency, Severity, and Disability with Eptinezumab in Adults with Chronic Migraine: Results from the PREVAIL Trial. [PDF]

Pain Ther
Starling AJ, Kudrow D, Kapur N, Awad SF, Grossman SW, Patel F, Ailani J, Blumenfeld A, Lipton RB.   +8 more
europepmc   +1 more source

Effects of Sodium Reduction on the Physicochemical Characteristics of Pretzel Bites. [PDF]

J Food Sci
Cabrera RPC, Aguilar PT, Ozturk OK, Khan N, Dolcos F, Torrico DD.   +5 more
europepmc   +1 more source

CTLA4-Ig + Anti-IL-6/IL-6R Treatment Results in Long-term Allograft Survival and Function in Highly HLA-sensitized Patients. [PDF]

Transplant Direct
Jordan SC, Chandran S, Ammerman N, Huang E, Shoji J, Zhang X, Peng A, Shin B, Thomas D, Najjar R, Kumar S, Heeger P, Vo A.   +12 more
europepmc   +1 more source