Results 61 to 70 of about 865,993 (309)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Introducing Probabilistic Models for Redundant System Reliability

Operations Research and Decisions, 2016
Probabilistic models have been developed to evaluate the relationship between reliability measures and the performance of a repairable network with built in redundancy.
Mansur Babagana, Bello Gimba, Ibrahim Yusuf   +2 more
doaj  

Redundancy Analysis and Elimination on Access Patterns of the Windows Applications Based on I/O Log Data

IEEE Access, 2020
In this paper, we analyze I/O log data monitored in the Windows operating system for improving the system performance. Especially, we focus on the I/O operations to the Windows registry.
Jun-Ha Lee, Hyuk-Yoon Kwon
doaj   +1 more source

Extended Non-Binary Low-Density Parity-Check Codes over Erasure Channels

, 2011
Based on the extended binary image of non-binary LDPC codes, we propose a method for generating extra redundant bits, such as to decreases the coding rate of a mother code.
Declercq, David, Savin, Valentin, Sy, Lam Pham   +2 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Leadership Redundancy in a Multiteam System [PDF]

, 2012
Inspection, maintenance, and repair (IMR) operations of the subsea infrastructure off Norway’s coast are performed from specialized vessels by multiteam systems. A case study shows how leadership is organized and practiced to coordinate interdependencies, and to cope with the risks inherent in this type of complex and tightly coupled operation ...
Johannessen, Idar A., McArthur, Philip W., Jonassen, Jan A.   +2 more
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Signaling System Fully Redundant On-board Architecture Suitable for TACS

Chengshi guidao jiaotong yanjiu
Objective The signaling system of Shanghai Rail Transit Line 3 and Line 4 can no longer meet the requirements of high-density and high-reliability networked operation, necessitating an upgrade to TACS (train autonomous circumambulate system).
NI Zhihao
doaj   +1 more source

A Fault-Tolerant Data Fusion Method of MEMS Redundant Gyro System Based on Weighted Distributed Kalman Filtering

Micromachines, 2019
The application of the Micro Electro-mechanical System (MEMS) inertial measurement unit has become a new research hotspot in the field of inertial navigation.
Binhan Du, Zhiyong Shi, Jinlong Song, Huaiguang Wang, Lanyi Han   +4 more
doaj   +1 more source