Results 241 to 250 of about 174,368 (349)

Procurement of Senonian Flint for Bladelets Production at the Early PPNB Site of Nahal Zahal in the Northern Negev Established for the First Time Using Chemical Composition Analysis

open access: yesArchaeometry, EarlyView.
ABSTRACT The hypotheses of Senonian flint to be a prime source of prehistoric “chalcedony” flint artefacts from the Negev Desert (Israel) was not investigated in detail thus far. By combining trace‐element profiling with statistical interpretation, ten flint items from Nahal Zahal, an Early Pre‐Pottery Neolithic B site in the northern Negev, were ...
Meir Finkel   +5 more
wiley   +1 more source

Methaemoglobinaemia: From pathophysiology to contemporary clinical management

open access: yesBritish Journal of Haematology, EarlyView.
Summary Methaemoglobin (MetHb) is an oxidised form of haemoglobin (Hb) unable to bind oxygen. Raised levels of MetHb reduce the blood's oxygen‐carrying capacity, causing potentially severe hypoxaemia and possible death. The condition arises from three main pathologies: mutations in globin genes causing Haemoglobin‐M, inherited deficiency of the enzyme ...
Alexander J. Twine, David C. Rees
wiley   +1 more source

Denialist vs. warmist climate change conspiracy beliefs: Ideological roots, psychological correlates and environmental implications

open access: yesBritish Journal of Psychology, EarlyView.
Abstract In the current research, we use network analysis to examine the structure, ideological foundations and correlates of climate change conspiracy theories, distinguishing between denialist and warmist beliefs. Denialist beliefs, typically endorsed on the political right, claim that climate change is exaggerated, whereas warmist beliefs, more ...
Dylan de Gourville   +2 more
wiley   +1 more source

Elemental redistribution in tropical soils: insights into REE, U, and Th mobility after extended phosphogypsum use. [PDF]

open access: yesEnviron Geochem Health
Tanure LPP   +7 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown   +2 more
wiley   +1 more source

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh   +5 more
wiley   +1 more source

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