Results 51 to 60 of about 548,213 (232)

Benchmarking the benchmarks: A mixture-of-experts model of heterogeneous reference points in laptop choice

Computers in Human Behavior Reports
Consumers rarely evaluate multi-attribute products on absolute levels alone; instead, they judge each option relative to salient reference points — either external benchmarks (e.g., the best, worst, or average option available) or internal anchors based ...
Ping Wang
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Beyond Conventional Transcriptional Regulation Function: FOXP3 as an Integrative Hub for Chromatin Interactions and Protein Complexes in Immune Regulation

Biology
As the lineage-defining transcription factor for regulatory T cells (Tregs), FOXP3 plays a critical role in maintaining immune homeostasis. However, FOXP3 has not been found to regulate the expression of immune suppressive cytokines so far, and the ...
He Chang, Yongqiang Wang, Li Gao, Shijun J. Zheng   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Use of a Deep Recurrent Neural Network to Reduce Wind Noise: Effects on Judged Speech Intelligibility and Sound Quality

Trends in Hearing, 2018
Despite great advances in hearing-aid technology, users still experience problems with noise in windy environments. The potential benefits of using a deep recurrent neural network (RNN) for reducing wind noise were assessed.
Mahmoud Keshavarzi, Tobias Goehring, Justin Zakis, Richard E. Turner, Brian C. J. Moore   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Considering evacuees’ route preferences in emergency evacuation: a route choice model based on mental accounting theory

Transportation Research Interdisciplinary Perspectives
The increasing number of natural disasters has heightened the need for evacuation. During evacuation, route choices of evacuates are affected by the road condition and evacuees’ reference-dependent evaluations.
Lu Yang, Xiaowei Hu, Xie Yu, Zhang Yantang, An Shi   +4 more
doaj   +1 more source

A study of the user's perception of economic value in nursing visits to primary care by the method of contingent valuation

BMC Family Practice, 2011
Background The identification of the attribution of economic value that users of a health system assign to a health service could be useful in planning these services. The method of contingent valuation can provide information about the user's perception
Conde-López Juan, Ariza-Cardiel Gloria, Domínguez-Bidagor Julia, Polentinos-Castro Elena, Rodríguez-Martínez Gemma, Tello Bernabé Eugenia, del Cura-González Isabel, Gómez-Gascón Tomás, Pérez-Rivas Francisco, Martín-Fernández Jesús, Beamud-Lagos Milagros, Aguado-Arroyo Óscar, Sanz-Bayona Teresa, Gil-Lacruz Ana   +13 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Assessment of visual quality and social perception of cultural landscapes: application to Anyi traditional villages, China

Heritage Science
The assessment of landscape visual quality (LVQ) holds significant importance in the preservation and advancement of traditional villages. One challenge in measuring human perception lies in establishing a connection between public preferences and ...
Ning Kang, Chunqing Liu
doaj   +1 more source