Results 61 to 70 of about 548,213 (232)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Iduronate Ring Puckering Effects on Preferred Glycosidic Linkage Conformations in Heparin/Heparan Sulfate and Dermatan Sulfate Disaccharides

Molecules
The conformation of a glycosaminoglycan (GAG) carbohydrate biopolymer is dependent upon the ring puckering states of its constituent monosaccharide residues and the dihedral angles (φ, ψ) of the glycosidic linkages connecting these residues.
Olgun Guvench
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

The Complex Relationship Between Education and Happiness: The Case of Highly Educated Individuals in Italy [PDF]

, 2019
The present work aims to explore whether there exists a systematic frustration in terms of income expectations among those who have obtained high level of education in Italy, and if this mismatch between expected and effective incomes negatively affects ...
Ruiu, Gabriele, Ruiu, Maria
core   +2 more sources

Les théories de l’accessibilité référentielle et la résolution des rapports anaphoriques ambigus au sein des textes classiques

TIPA. Travaux interdisciplinaires sur la parole et le langage, 2015
The work on the textual organization (Apotheloz, 1995; Grobet, 2000; Combettes, 1986) have demonstrated the great importance that played the management of pronouns anaphoric in structuring textual.
Achraf Ben Arbia
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Evolutionary smart contracts for virtual power plant trading: integrating prospect theory and multi-stage negotiation in cross-regional energy markets

International Journal of Electrical Power & Energy Systems
Virtual Power Plant (VPP) trading mechanisms confront unprecedented challenges from behavioral complexities and technological uncertainties that conventional rational choice models inadequately address.
Lefeng Cheng, Mengya Zhang, Kun Wang, Minmin Yuan, Zhiqiang Liu, Jie Wang, Kuozhen Zhang, Pengrong Huang   +7 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Exploring the values and preferences of children and adolescents with obesity and their parents/caregivers concerning diet or physical activity interventions for weight management: Mega-ethnography of qualitative syntheses.

PLoS ONE
IntroductionObesity and overweight are a global health problem affecting over 2.6 billion people worldwide. Diet and physical activity, including structured exercise, are critical components in the management of obesity.
Munira Essat, Christopher Carroll, Andrew Booth, Joanna Leaviss, Diana Castelblanco Cuevas, Roos Verstraeten   +5 more
doaj   +1 more source