Results 51 to 60 of about 513,542 (256)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Ten common issues with reference sequence databases and how to mitigate them

Frontiers in Bioinformatics
Metagenomic sequencing has revolutionized our understanding of microbiology. While metagenomic tools and approaches have been extensively evaluated and benchmarked, far less attention has been given to the reference sequence database used in metagenomic ...
Samuel D. Chorlton
doaj   +1 more source

Driving mosaicism: somatic variants in reference population databases and effect on variant interpretation in rare genetic disease

Human Genomics, 2021
Background Genetic variation databases provide invaluable information on the presence and frequency of genetic variants in the ‘untargeted’ human population, aggregated with the primary goal to facilitate the interpretation of clinically important ...
Vladimir Avramović, Simona Denise Frederiksen, Marjana Brkić, Maja Tarailo-Graovac   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Formalization of regulatory information (using the example of SR 30.13330.2020 Internal water supply and sewerage of building) [PDF]

BIO Web of Conferences
The article is devoted to the development of databases of the factographic reference system. The method of formalization of normative information is proposed. The classification of tables into “descriptive” and “prescriptive” has been introduced.
Kitaytseva Elena
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Analysis of international experience in creating reference standards databases

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article analyses international experience in creating analytical databases with information on reference standards. The authors examined and compared publicly available databases, i.e. reference standards catalogues posted on the official websites of
A. V. Kozlovich, V. N. Kotikov, L. V. Korsun, S. A. Kalinichev   +3 more
doaj  

Linking Virus Genomes with Host Taxonomy

Viruses, 2016
Environmental genomics can describe all forms of organisms—cellular and viral—present in a community. The analysis of such eco-systems biology data relies heavily on reference databases, e.g., taxonomy or gene function databases.
Tomoko Mihara, Yosuke Nishimura, Yugo Shimizu, Hiroki Nishiyama, Genki Yoshikawa, Hideya Uehara, Pascal Hingamp, Susumu Goto, Hiroyuki Ogata   +8 more
doaj   +1 more source

Proteogenomics Reference Database Protocol v1

, 2022
Therapeutic approaches to treat melanoma include small molecule drugs that target activating protein mutations in pro-growth signaling pathways like the MAPK pathway. While beneficial to the approximately 50% of patients with activatingBRAFV600mutation, mono- and combination therapy with MAPK inhibitors is ultimately associated with acquired resistance.
Kanishka Manna, Prashanthi Dharanipragada, Duah Alkam, Nathan L. Avaritt, Charity L. Washam, Tung-chin Chiang, Michael S Robeson, Ricky D. Edmondson, Samuel G. Mackintosh, Zhentao Yang, Yan Wang, Shirley H. Lomeli, Gatien Moriceau, Roger S. Lo, Alan J. Tackett, Stephanie D. Byrum   +15 more
openaire   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source