Results 141 to 150 of about 15,634,829 (260)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

DO BATUQUE DO ATABAQUE À DECISÃO DE COMPRA: Pais e Mães de Santo Podem Influenciar no Consumo Sagrado e Profano de Seus Seguidores?

Perspectivas Contemporâneas, 2016
This paper aims to determine whether, through Orishas and entities, holy fathers and mothers can influence the sacred and profane consumption behavior of the followers of Candomblé and Umbanda in Brazil.
Ohana Trajano Barbosa, Mariana Bueno de Andrade Matos, Francisco Vicente Sales Melo, Maria de Lourdes de Azevedo Barbosa, Salomão Alencar de Farias   +4 more
doaj  

Tick-borne lymphadenopathy in northeastern France: a human and vector clinical–epidemiological study

Parasites & Vectors
Background Tick-borne lymphadenopathy (TIBOLA) is a tick-borne disease transmitted by Dermacentor ticks and is usually caused by Rickettsia. In 2021, clinicians in northeastern France reported an increase in TIBOLA cases.
Jeanne Kotzyba, Elisabeth Baux, Yves Hansmann, Pierre Boyer, Benoît Jaulhac, Martin Martinot, Benoît Martha, Charlotte Kaeuffer, Thomas Bonijoly, Firouzé Bani-Sadr, Antoine Legoff, Florence Hoefler, Mathieu Blot, Loïc Bourdellon, Laurence Zilliox, Nathalie Boulanger, Benjamin Lefevre   +16 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Ethnopolitical Entrepreneurship and the Political Role of Saxonness without Saxons in Sibiu

Sociologie Românească, 2011
The paper discusses the symbolic capital of Saxonness in the Romanian and Transylvanian public sphere and its uses as a political and cultural resource.
Monica Stroe
doaj  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Proposed Plasma Ammonia Reference Intervals in a Reference Group of Hospitalized Term and Preterm Neonates. [PDF]

J Appl Lab Med, 2020
Madigan T, Block DR, Carey WA, Kaemingk BD, Patel R.   +4 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source