Results 231 to 240 of about 15,634,829 (260)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Timing of lactated Ringer's administration relative to Sepsis-3 diagnosis and 28-day mortality: A retrospective propensity score-matched cohort study. [PDF]

SAGE Open Med
Huang Y, Zou J.
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Comparative outcomes of delta-on-delta and delta-on-highly cross-linked polyethylene bearings in total hip arthroplasty: a nationwide cohort study. [PDF]

Arch Orthop Trauma Surg
Lee YK, Kang D, Kim H, Kang E, Cho J, Park JW.   +5 more
europepmc   +1 more source

Association of ABO Blood Groups with HPV Genotypes and Cervical Lesions in HPV-Positive Women. [PDF]

Int J Womens Health
Adan R, Şirinoğlu HA, Kaban A, Taşdemir D, Yılmaz M, Şahin F, Kinter AK.   +6 more
europepmc   +1 more source

Exploring trop-2-directed ADCs monotherapy and combination therapy in pretreated mTNBC: a real-world study. [PDF]

Breast Cancer Res Treat
Liu J, Ding L, Wang J, Chen T, Long T, Li Q, Chai J, Yao H, Wang Y, Zhao J.   +9 more
europepmc   +1 more source

A Study on the Depressive Symptoms and Life Satisfaction Among Middle-Aged and Older Adults in China Based on CHARLS 2020 Data. [PDF]

Behav Sci (Basel)
Wang S, Shirayama Y, Ahmad I, Okamoto M, Yuasa M.   +4 more
europepmc   +1 more source

Establishing preliminary normative reference values for oral motor skills in typically developing Egyptian children using oral placement therapy tools. [PDF]

BMC Pediatr
Zaytoun RAE, Abdel Hady AF, Farag ME, Alasheery RA, Gomaa MM, Amin SM.   +5 more
europepmc   +1 more source