Results 191 to 200 of about 18,500,807 (388)

Mass‐Independent and Mass‐Dependent Ca Isotopic Compositions of Thirteen Geological Reference Materials Measured by Thermal Ionisation Mass Spectrometry

, 2017
Yongsheng He, Yang Wang, Chuanwei Zhu, Shichun Huang, Shuguang Li   +4 more
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Generation of quartet reference materials for preimplantation genetic testing for structural rearrangements. [PDF]

BMC Genomics
Sun N, Zhang W, Yu D, Zhang M, Zou Y, Dong X, Wang Y, Song N, Guo Y, Jiang C, Wang W, Kong L, Liang B, Fei J, Lu S, Peng Z, Yu T, Xiang J, Qu S.   +18 more
europepmc   +1 more source

Elaboration of reference material for cadmium and arsenic in hydrobiological products, for the purpose of being used in a laboratory intercomparation program

, 2021
Soraya Sandoval, Karina González, Luis Muñoz   +2 more
openalex   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A New Class of Reference Material: Additivly Manufactured Monodisperse Number Accurate Microplastic Reference Material through Microextrusion [PDF]

Kathrin Harre, Maurice Hauffe, Lucas Kurzweg, Robert Möhn, Tilmann Priebe, Thomas Himmer   +5 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A novel approach to the production of Δ⁹-THC and CBN certified reference materials. [PDF]

Anal Bioanal Chem
de Carvalho LJ, Lopes SRP, Cesar KE, Chaves DSA, da Frota LCRM, de Menezes Epifanio NM, Finelli FG, Garrido BC.   +7 more
europepmc   +1 more source

Isotope-dilution anchoring of zircon reference materials for accurate Ti-in-zircon thermometry

, 2018
D. Szymanowski, M. Fehr, M. Guillong, M. Coble, J. Wotzlaw, L. Nasdala, B. Ellis, O. Bachmann, M. Schönbächler   +8 more
semanticscholar   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source