Results 211 to 220 of about 17,068,399 (395)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Stable Isotope Reference Materials and Scale Definitions-Outcomes of the 2024 IAEA Experts Meeting. [PDF]

Rapid Commun Mass Spectrom
Camin F, Besic D, Brewer PJ, Allison CE, Coplen TB, Dunn PJH, Gehre M, Gröning M, Meijer HAJ, Hélie JF, Iacumin P, Kraft R, Krajnc B, Kümmel S, Lee S, Meija J, Mester Z, Mohn J, Moossen H, Qi H, Skrzypek G, Sperlich P, Viallon J, Wassenaar LI, Wielgosz RI.   +24 more
europepmc   +1 more source

Application of the loop method to the preparation of gas reference material

, 2019
Zheng Fang, Xin Zhou, Zhiang Li, Fanfeng Deng, Liaoyu Dong, Liwen Zheng   +5 more
openalex   +1 more source

Supplementary Materials and Methods, reference, Figure Legends from miR340 Suppresses the Stem-like Cell Function of Glioma-Initiating Cells by Targeting Tissue Plasminogen Activator

, 2023
Daisuke Yamashita, Toru Kondo, Shiro Ohue, Hisaaki Takahashi, Madoka Ishikawa, Ryo Matoba, Satoshi Suehiro, Shohei Kohno, Hironobu Harada, Junya Tanaka, Takanori Ohnishi   +10 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

How Well Do We Know VPDB-Part 2: Interlaboratory Assessment of Existing δ¹³C_VPDB Reference Materials. [PDF]

Rapid Commun Mass Spectrom
Moossen H, Steur PM, Camin F, Krajnc B, Enke A, Geilmann H, Paul D, Lange M, von Rein I, Meijer HAJ.   +9 more
europepmc   +1 more source

Reference Material

TRENDS IN THE SCIENCES, 1997
openaire   +2 more sources

Matrix Reference Materials to Support Biomonitoring Analysis: A PARC Training Resource

Marina Ricci, Đorđe Tadić
openalex   +1 more source

Development of Pure Certified Reference Material of Cannabidiol [PDF]

Congcong Yu, Ruihan Long, Feng Cao, Xinying Zhao, Tao Lan, Dunming Xu   +5 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source