Results 161 to 170 of about 976,097 (313)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Research progress on fertility information needs and support in male cancer patients of reproductive age

Huli yanjiu
This article reviewed the current status of fertility information needs among male cancer patients of reproductive age and the factors influencing their access to fertility⁃related information support.Strategies to improve fertility information support ...
FENG Shengya, GAO Rong, ZHAI Linjun, LIU Rong, ZHENG Jie   +4 more
doaj  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

The Mediating Role of Interpersonal Needs in Perceived Parenting Styles and Social Media Addiction Among University Students: Cross-Sectional Study. [PDF]

J Med Internet Res
Liu Y, Wang S, Wei T, Wu B, Ge X, Liu S, Xu C, Tao S, Fan X, Hu F, Wang Y, Yang X, Cai Y.   +12 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Usability, Relevance, and User Engagement of a Government-Sponsored and Community Co-Designed Digital Mental Health Website During the COVID-19 Pandemic: A Pilot Study on Latino/a/x Adults. [PDF]

JMIR Form Res
Wright B, Zhang L, Meza JI, Rodriguez L, Contreras I, Terán V, Young AS, Nuño M, Dzou T, Aguilar-Gaxiola S, Wells KB.   +10 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Report of the TAC Subcommittee Mission to Review the Research Needs for Protein Production in Tropical America

, 1973
Report of the mission sent to review research needs for protein production in tropical America. Background, terms of reference, and itinerary of the mission.
CGIAR Technical Advisory Committee Subcommittee Review Mission on Research Needs for Protein Production in Tropical America
core  

The Association Between Shared Decision-Making and Child Health in the General Pediatric Population. [PDF]

Matern Child Health J
Cohen A, Michelson KN, Macy ML, Heard-Garris N, Kan K.   +4 more
europepmc   +1 more source