Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
La courbe au point. Se poser des questions ; réflexe le plus humain ?
, 2016 La courbe au point est le début d’une petite aventure intellectuelle que j’aimerais partager avec d’éventuels lecteurs et – pour mon plus grand bonheur – discutants et/ou contradicteurs.
Mathieu Fusi
core
A multi-objective particle swarm algorithm based on hierarchical clustering reference point maintenance. [PDF]
Sci RepChen S, Liu Y, Yang J, Ouyang A, Yu J.
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
HPV Vaccine Uptake and Cervical Cancer Trends in Panama: A Reference Point for Future Impact Studies. [PDF]
Vaccines (Basel)Calvo A +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Reference Point and Grid Method-Based Evolutionary Algorithm with Entropy for Many-Objective Optimization Problems. [PDF]
Entropy (Basel)Leng Q, Shan B, Zhou C.
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A dual-population Constrained Many-Objective Evolutionary Algorithm based on reference point and angle easing strategy. [PDF]
PeerJ Comput SciJi C, Wu L, Zhao T, Cai X.
europepmc +1 more source
Automatic configuration of the reference point method for fully automated multi-objective treatment planning applied to oropharyngeal cancer. [PDF]
Med Phys, 2020 van Haveren R, Heijmen BJM, Breedveld S.
europepmc +1 more source