Results 251 to 260 of about 2,154,603 (302)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

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Reference-Point Formation and Updating

Management Science, 2011
Reference-dependent preferences have been well accepted in decision sciences, experimental economics, behavioral finance, and marketing. However, we still know very little about how decision makers form and update their reference points given a sequence of information.
Manel Baucells, Martin Weber
exaly   +3 more sources

The gender reference point gap

SSRN Electronic Journal, 2023
This paper examines how men and women differ in their attitudes towards taking risks. In many studies women have been found to be less willing to take risks than men, and this gender difference can have an impact on economic opportunities and outcomes for women.
Kettlewell, Nathan, Levy, Jonathan, Tymula, Agnieszka, Wang, Xueting   +3 more
openaire   +4 more sources

The Effect of Reference Point on Stochastic Network Equilibrium

Transportation Science, 2006
Following studies of human decision making under risk and uncertainty, an extensive evidence of loss aversion and asymmetric risk-taking behavior around a reference point was found.
Erel Avineri
exaly   +2 more sources

Reference points and roughness

Information Sciences, 2010
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Babushri Srinivas Kedukodi, Syam Prasad Kuncham, Satyanarayana Bhavanari   +2 more
openaire   +2 more sources

Goals as Reference Points

Cognitive Psychology, 1999
We argue that goals serve as reference points and alter outcomes in a manner consistent with the value function of Prospect Theory (Kahneman & Tversky, 1979; Tversky & Kahneman, 1992). We present new evidence that goals inherit the properties of the value function-not only a reference point, but also loss aversion and diminishing sensitivity.
C, Heath, R P, Larrick, G, Wu
openaire   +2 more sources

Point of Reference

Leonardo, 1993
GEO-SONIC (1988) is an artwork for computer that explores sound, language and geographics. It is a collage of sounds, speech and calligraphy from around the world that leads the participant in associative global dreams and journeys. Sounds sampled by the artists are digitized and played back, juxtaposed with on-screen visual imagery (by use of a track ...
Madelon Hooykaas, Elsa Stansfield
openaire   +1 more source