Results 61 to 70 of about 697,216 (217)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Virtual Reference Services

International Journal of Librarianship
This study examined key findings relevant to library practitioners' experiences with virtual reference services, or VRS. It did this by examining skills, training experiences, perspectives, and challenges encountered during VRS implementation.
Jimson Napoleon Mariano
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Beta Spaces as a Model for Recontextualizing Reference Services in Libraries

In the Library with the Lead Pipe, 2016
In Brief: Reference services are at a cross-roads. While many academic libraries continue to offer reference services from behind a desk, others are moving to roving and embedded reference models.
Madelynn Dickerson
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Provision of digital reference services in academic libraries in Kenya: a review

Regional Journal of Information and Knowledge Management, 2017
Rationale of the study - The popularity of internet as an avenue of communication and source of information has led to decreasing numbers of in-person reference transaction in academic libraries.
James M. Tutu
doaj  

Readers’ advisory guide development for webtoon

Information Research: An International Electronic Journal
Introduction. Readers’ advisory (RA) services are one of the core information services that libraries provide. As the types and formats of the collection materials have diversified, relevant RA services have evolved accordingly. This project develops an
Hyerim Cho, Denice Adkins, Hillary Gould, Katy Bond, Ky Flood   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

They CAN and they SHOULD and it’s BOTH AND: The role of undergraduate peer mentors in the reference conversation

In the Library with the Lead Pipe, 2018
In Brief: Academic libraries hire and train student employees to answer reference questions which can result in high-impact employment experiences for these students. By employing students in this role, opportunities are created for peer-to-peer learning
Hailley Fargo
doaj  

Intervention design for artificial intelligence-enabled macular service implementation: a primary qualitative study

Implementation Science Communications
Background Neovascular age-related macular degeneration (nAMD) is one of the largest single-disease contributors to hospital outpatient appointments. Challenges in finding the clinical capacity to meet this demand can lead to sight-threatening delays in ...
Henry David Jeffry Hogg, Katie Brittain, James Talks, Pearse Andrew Keane, Technology Enhanced Macular Services Study Reference Group, Gregory Maniatopoulos   +5 more
doaj   +1 more source