Results 51 to 60 of about 6,893,172 (292)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Standards of Diagnostic Validation: Recommendations for Reference Collections

open access: yesPhytoFrontiers, 2023
Agricultural and ecosystem biosecurity requires accurate and reliable diagnostic data provided by systems of people, technologies, and validated diagnostic assays.
Carrie L. Harmon   +9 more
doaj   +1 more source

A simple airlfow path approach to sizing natural ventilation systems in a code context [PDF]

open access: yes, 2009
Most of the existing ventilation standards are drafted in a rather prescriptive way. Growing focus on the implementation of rational energy use however, introduces an urgent need for more performance-based criteria.
Janssens, Arnold, Laverge, Jelle
core   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

An annotation scheme and gold standard for Dutch-English word alignment [PDF]

open access: yes, 2010
The importance of sentence-aligned parallel corpora has been widely acknowledged. Reference corpora in which sub-sentential translational correspondences are indicated manually are more labour-intensive to create, and hence less wide-spread.
Macken, Lieve
core  

A Theory of Names and True Intensionality [PDF]

open access: yes, 2012
Standard approaches to proper names, based on Kripke's views, hold that the semantic values of expressions are (set-theoretic) functions from possible worlds to extensions and that names are rigid designators, i.e.\ that ...
Muskens, Reinhard
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman   +8 more
wiley   +1 more source

Update on Non-Interchangeability of Botulinum Neurotoxin Products

open access: yesToxins
The growing use of botulinum neurotoxins (BoNTs) for medical and aesthetic purposes has led to the development and marketing of an increasing number of BoNT products.
Mitchell F. Brin   +4 more
doaj   +1 more source

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