Results 111 to 120 of about 9,142,402 (345)

Evaluating EGFR Genotyping using HDx™ Reference Standards [PDF]

, 2015
Marsha Speevak, Chantal Murray
openalex   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

The lipidomics reporting checklist a framework for transparency of lipidomic experiments and repurposing resource data

Journal of Lipid Research
The rapid increase in lipidomic studies has led to a collaborative effort within the community to establish standards and criteria for producing, documenting, and disseminating data. Creating a dynamic easy-to-use checklist that condenses key information
Dominik Kopczynski, Christer S. Ejsing, Jeffrey G. McDonald, Takeshi Bamba, Erin S. Baker, Justine Bertrand-Michel, Britta Brügger, Cristina Coman, Shane R. Ellis, Timothy J. Garrett, William J. Griffiths, Xue Li Guan, Xianlin Han, Marcus Höring, Michal Holčapek, Nils Hoffmann, Kevin Huynh, Rainer Lehmann, Jace W. Jones, Rima Kaddurah-Daouk, Harald C. Köfeler, Peter J. Meikle, Thomas O. Metz, Valerie B. O’Donnell, Daisuke Saigusa, Dominik Schwudke, Andrej Shevchenko, Federico Torta, Juan Antonio Vizcaíno, Ruth Welti, Markus R. Wenk, Denise Wolrab, Yu Xia, Kim Ekroos, Robert Ahrends, Gerhard Liebisch   +35 more
doaj   +1 more source

Gamma camera-specific reference standards for radioactive iodine uptake measurements. [PDF]

EJNMMI Phys, 2023
Mourik JEM, Derks M, Te Beek ET, Ten Broek MRJ.   +3 more
europepmc   +1 more source

Applicability of carbonate reference materials as matrix-matched standards for in-situ LA-ICPMS U-Pb dating of Sulphates 

, 2021
Aratz Beranoaguirre, Iuliana Vasiliev, Axel Gerdes   +2 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Prehospital early warning scores for adults with suspected sepsis: the PHEWS observational cohort and decision-analytic modelling study

Health Technology Assessment
Background Guidelines for sepsis recommend treating those at highest risk within 1 hour. The emergency care system can only achieve this if sepsis is recognised and prioritised.
Steve Goodacre, Laura Sutton, Kate Ennis, Ben Thomas, Olivia Hawksworth, Khurram Iftikhar, Susan J Croft, Gordon Fuller, Simon Waterhouse, Daniel Hind, Matt Stevenson, Mike J Bradburn, Michael Smyth, Gavin D Perkins, Mark Millins, Andy Rosser, Jon Dickson, Matthew Wilson   +17 more
doaj   +1 more source