Results 81 to 90 of about 11,084,989 (407)

The Dutch interbank computer network [PDF]

, 1988
At the end of 1980, a strategic decision was made by the Dutch banks and savings banks to commence the development of a Data Communications Infrastructure (DCI), to be used for a number of forthcoming interbank applications.
Michiels, Eddie
core   +4 more sources

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

The intellectual and moral integrity of bioethics: response to commentaries on A case study in unethical transgressive bioethics: \u27Letter of concern from bioethicists\u27 about the prenatal administration of dexamethasone . [PDF]

, 2010
In our target article we showed that the Letter of Concern (LoC) fails to meet accepted standards for presenting empirical data for the purpose of supplementing a normative claim and for argument-based normative ethics.
Brent, Robert L, Chervenak, Frank A, Hippen, Benjamin, McCullough, Laurence B   +3 more
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Reference Phase of Fresnel Zone Plates [PDF]

arXiv, 2003
The standard zone plate assumes that the shortest ray connecting a radiation source and a detection point has a phase of 0 deg thereby defining a reference phase. Here we examine the experimental consequences of varying this reference phase from 0 deg to 360 deg. It is concluded that reference phase is an intrinsic and useful property of zone plates.
arxiv  

Human-Paraphrased References Improve Neural Machine Translation [PDF]

arXiv, 2020
Automatic evaluation comparing candidate translations to human-generated paraphrases of reference translations has recently been proposed by Freitag et al. When used in place of original references, the paraphrased versions produce metric scores that correlate better with human judgment.
arxiv  

Application of shape grammar theory to underground rail station design and passenger evacuation [PDF]

, 2012
This paper outlines the development of a computer design environment that generates station ‘reference’ plans for analysis by designers at the project feasibility stage.
Ceranic, Boris, Smith, Graham
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Evaluating Optimal Reference Translations [PDF]

arXiv, 2023
The overall translation quality reached by current machine translation (MT) systems for high-resourced language pairs is remarkably good. Standard methods of evaluation are not suitable nor intended to uncover the many translation errors and quality deficiencies that still persist. Furthermore, the quality of standard reference translations is commonly
arxiv