Results 101 to 110 of about 30,058,457 (307)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Transformation of coordinate systems: software, limits and potentialities

open access: yesForest@, 2004
The use of different reference systems has involved the need of suitable methodologies for the transformation between coordinate systems. Nowadays such a need is done strong because of the diffusion of Geographical Information Systems (GIS) and by the ...
doaj  

The reference system in product generation engineering: structuring reference system elements for advanced systems engineering based on the system triple

open access: yesDesign Science
Product engineering in general and advanced systems engineering in specific are highly complex and unique processes that strive to deliver innovations – successful new products.
Albert Albers   +7 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

IS RUSSIA READY FOR THE INTRODUCTION OF THE NATIONAL REFERENCE PRICING SYSTEM?

open access: yesФармакоэкономика, 2015
the analysis of foreign pricing and drug supply public funding systems (or a so-called drug reimbursement) shows a substantial variety and presence of national peculiarities; however the majority of the developed foreign countries apply reference pricing.
V. V. Omelyanovskiy
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Prevalence of crimean Congo hemorrhagic fever in Khyber Pakhtunkhwa, Pakistan

open access: yesTravel Medicine and Infectious Disease
Background: CCHFV is well recognized as a major public health threat and its prevalence and epidemiological distribution in Pakistan and specifically in KP province is not well documented.
Asad Zia   +8 more
doaj   +1 more source

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